Recombinant Anti-human Aβ Intrabody [Tat]
CAT#: IAB-B052(T)
Recombinant anti-Aβ intrabody in fusion with HIV Tat works within cells to bind amyloidogenic protein fragment Aβ, expressed in 293T cells. Intrabodies have shown efficacy in blocking the toxicity of Aβ in cell culture and paving the way for clinical trials of these reagents in brain disorders.
Specifications
- Immunogen
- human Amyloid beta
- Host Species
- human
- Type
- scFv-Tat
- Cell Penetrating Peptide
- TAT
TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
- Species Reactivity
- human
- Applications
- Formats of immunological tests: Protein fragment complementation; Western blot; Functional studies
Product Property
- Purity
- >97%, by SDS-PAGE under reducing conditions
- Storage
- 4 °C, -20°C if preferred
Target
- Alternative Names
- Amyloid beta; Aβ; Abeta
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
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| TAB-610CT-S(P) | Mouse Anti-Aβ Recombinant Antibody; scFv Fragment (TAB-610CT-S(P)) | ELISA | Mouse scFv |
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| Gly-160LC-1 | Recombinant Anti-Human Aβ Antibody (Fc glycosylation/Sialylated) | ELISA | Mouse antibody |
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| HPAB-0959WJ-S(P) | Human Anti-Aβ Recombinant Antibody; scFv Fragment (HPAB-0959WJ-S(P)) | ELISA | Humanized scFv |
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