Anti-CCNE1 Intrabody [+36GFP] (IAB-B078(G))

Recombinant anti-CCNE1 intrabody in fusion with +36GFP works within cells and specifically reacts with CCNE1, expressed in E. coli cells. Anti-cyclin E single-chain antibodiess (sFvs) are used to block cyclin E function in normal and breast cancer cells.      

human cyclin E1
Cell Penetrating Peptide
TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
Species Reactivity
Formats of immunological tests: Protein fragment complementation; Western blot; Functional studies
Alternative Names
CCNE1; cyclin E1; CCNE; G1/S-specific cyclin-E1; cyclin Es; cyclin Et; cyclin E variant ex5del; cyclin E variant ex7del
Entrez Gene ID
UniProt ID

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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