Human Anti-CDH15 Recombinant Antibody (clone PPAT-057-17C); Fab Fragment (CAT#: HPAB-0224-CN-F(E))
The chimeric antibody PPAT-057-17C was found to have strong reactivity with a CDH3-expressing cell line. The antitumor effects of the chimeric antibody PPAT-057-17C were confirmed using xenograft models, into which a human lung cancer-derived cell line NCI-H358 had been transplanted.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line RH-30
(Immunofluorescent staining of human cell line RH-30 shows localization to plasma membrane & the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9139/1165_D3_1_selected.jpg
(Immunofluorescent staining of human cell line RH-30 shows localization to plasma membrane & the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9139/1165_D3_1_selected.jpg
Figure 2 High expression in skeletal muscle
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9139/26256_B_3_6_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9139/26256_B_3_6_val_selected.jpg
Figure 3 Low expression in skin 1
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9139/26256_B_8_1_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9139/26256_B_8_1_val_selected.jpg
Figure 4 Skeletal muscle
(Myocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9139/26256_B_3_6.jpg
(Myocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9139/26256_B_3_6.jpg
Figure 5 RNA cell line category: Cell line enriched (RH-30)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000129910-CDH15
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000129910-CDH15
Specifications
- Host Species
- Human
- Derivation
- Chimeric (mouse/human)
- Type
- Chimeric (mouse/human) Fab
- Specificity
- Human CDH15
- Species Reactivity
- Human
- Clone
- PPAT-057-17C
- Applications
- ELISA, WB, FC
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Cadherin 15, Type 1, M-Cadherin (Myotubule); Cadherin-14; CDH14; CDH3; Cadherin 15, M-Cadherin (Myotubule); Muscle-Cadherin; Muscle Cadherin; Cadherin-3; M-Cadherin; CDHM; MCAD; MRD3
- Gene ID
- 1013
- UniProt ID
- P55291
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Fab Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0615 | Hi-Affi™ Rabbit Anti-CDH15 Recombinant Antibody (clone DS615AB) | WB | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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