Anti-CEACAM6-CL2A-SN-38 ADC
CAT#: ADC-147LZY
This ADC product is composed of an anti-CEACAM6 antibody conjugated via CL2A linker to SN-38 (CL2A-SN-38). It has demonstrated a response in breast tumors treatment by a MOA (Mechanism of Action) of inhibiting Topoisomerase I and causing DNA damage.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human duodenum
Immunohistochemical staining of human duodenum shows strong cytoplasmic positivity in a subset of leukocytes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11041/ihc_selected.jpg
Normal Tissue
Figure 2 High expression in lung.
Macrophages Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11041/27139_A_3_4.jpg
Normal Tissue
Figure 3 Colon
Enterocytes - Microvilli Staining: Medium Intensity: Moderate Mucosal lymphoid cells Staining: Medium Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11041/27139_A_9_3.jpg
Normal Tissue
Figure 4 Lymph node
Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11041/27139_A_8_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enriched (OE19)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000086548-CEACAM6
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Specifications
- Antibody Overview
- Humanized Anti-CEACAM6 mAb
- Linker
- CL2A
- Linker Class/Description
- Class: Enzymatically cleavable linker-Peptide linker
Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- SN-38(7-ethyl-10-hydroxy camptothecin)
- Drug Class/Description
- Class: SN-38
Description: SN38 (7-ethyl-10-hydroxy camptothecin) is an active metabolite of the cancer prodrug, irinotecan, with the ability of inhibiting Topoisomerase I, which is belong to the camptothecin family. SN-38 is formed via hydrolysis of irinotecan by carboxylesterases and metabolized via glucuronidation by UGT1A1
Target
- Introduction
- This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohns disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014]
- Alternative Names
- CEACAM6; carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen); NCA; CEAL; CD66c; carcinoembryonic antigen-related cell adhesion molecule 6; normal cross-reacting antigen; Cluster of Differentiation 66c;
- Gene ID
- 4680
- UniProt ID
- P40199
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Validated CEACAM6 Binding
This product effectively targets CEACAM6, a cell adhesion molecule expressed on various tumor cells. We used it to study the internalization dynamics in breast tumor cell lines. The binding was specific, and the subsequent biological effects confirmed the successful delivery of the payload.
SN-38 Topoisomerase Inhibition
The SN-38 payload in this ADC is a potent Topoisomerase I inhibitor. We observed significant DNA damage in cells treated with this conjugate, which differs from the mechanism of microtubule inhibitors. The CL2A peptide linker facilitated rapid enzymatic release in the target cells.
Q&As
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To which family does the SN-38 payload belong?
A: SN-38 belongs to the camptothecin family. It is an active metabolite of irinotecan. Its mechanism involves inhibiting Topoisomerase I, which leads to DNA damage and cell death, distinct from microtubule inhibitors.
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How is the CL2A linker described?
A: The CL2A linker is an enzymatically cleavable peptide linker. It is designed to be stable in the blood due to endogenous inhibitors of proteases but is rapidly cleaved by lysosomal enzymes inside the target cell, releasing the drug.
View the frequently asked questions answered by Creative Biolabs Support.
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COA
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