Anti-CEACAM6-CL2A-SN-38 ADC
CAT#: ADC-147LZY
This ADC product is composed of an anti-CEACAM6 antibody conjugated via CL2A linker to SN-38 (CL2A-SN-38). It has demonstrated a response in breast tumors treatment by a MOA (Mechanism of Action) of inhibiting Topoisomerase I and causing DNA damage.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human duodenum
Immunohistochemical staining of human duodenum shows strong cytoplasmic positivity in a subset of leukocytes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11041/ihc_selected.jpg
Normal Tissue
Figure 2 High expression in lung.
Macrophages Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11041/27139_A_3_4.jpg
Normal Tissue
Figure 3 Colon
Enterocytes - Microvilli Staining: Medium Intensity: Moderate Mucosal lymphoid cells Staining: Medium Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11041/27139_A_9_3.jpg
Normal Tissue
Figure 4 Lymph node
Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11041/27139_A_8_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enriched (OE19)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000086548-CEACAM6
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Specifications
- Antibody Overview
- Humanized Anti-CEACAM6 mAb
- Linker
- CL2A
- Linker Class/Description
- Class: Enzymatically cleavable linker-Peptide linker
Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- SN-38(7-ethyl-10-hydroxy camptothecin)
- Drug Class/Description
- Class: SN-38
Description: SN38 (7-ethyl-10-hydroxy camptothecin) is an active metabolite of the cancer prodrug, irinotecan, with the ability of inhibiting Topoisomerase I, which is belong to the camptothecin family. SN-38 is formed via hydrolysis of irinotecan by carboxylesterases and metabolized via glucuronidation by UGT1A1
Target
- Introduction
- This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohns disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014]
- Alternative Names
- CEACAM6; carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen); NCA; CEAL; CD66c; carcinoembryonic antigen-related cell adhesion molecule 6; normal cross-reacting antigen; Cluster of Differentiation 66c;
- Gene ID
- 4680
- UniProt ID
- P40199
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| TAB-444LC-F(E) | Anti-Human CEACAM6 Recombinant Antibody Fab Fragment (TAB-444LC-F(E)) | IHC, ELISA, FC, WB | Humanized antibody |
| TAB-446LC-F(E) | Human Anti-CEACAM6 Recombinant Antibody; Fab Fragment (TAB-446LC-F(E)) | WB, IHC | Humanized Fab |
| TAB-447LC-F(E) | Human Anti-CEACAM6 Recombinant Antibody; Fab Fragment (TAB-447LC-F(E)) | WB, IHC | Humanized Fab |
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| TAB-449LC-F(E) | Human Anti-CEACAM6 Recombinant Antibody; Fab Fragment (TAB-449LC-F(E)) | WB, IHC | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-445LC-F(E) | Mouse Anti-CEACAM6 Recombinant Antibody; Fab Fragment (TAB-445LC-F(E)) | ELISA, FC | Mouse Fab |
| TAB-477MZ-S(P) | Mouse Anti-CEACAM6 Recombinant Antibody; scFv Fragment (TAB-477MZ-S(P)) | ELISA | Mouse scFv |
| TAB-478MZ-S(P) | Mouse Anti-CEACAM6 Recombinant Antibody; scFv Fragment (TAB-478MZ-S(P)) | ELISA | Mouse scFv |
| TAB-477MZ-F(E) | Mouse Anti-CEACAM6 Recombinant Antibody; Fab Fragment (TAB-477MZ-F(E)) | ELISA | Mouse Fab |
| TAB-478MZ-F(E) | Mouse Anti-CEACAM6 Recombinant Antibody; Fab Fragment (TAB-478MZ-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0283-CN-S(P) | Human Anti-CEACAM6 Recombinant Antibody; scFv Fragment (HPAB-0283-CN-S(P)) | ELISA, WB, FC | Human scFv |
| HPAB-0284-CN-S(P) | Mouse Anti-CEACAM6 Recombinant Antibody; scFv Fragment (HPAB-0284-CN-S(P)) | ELISA, WB, FC | Mouse scFv |
| HPAB-0285-CN-S(P) | Mouse Anti-CEACAM6 Recombinant Antibody; scFv Fragment (HPAB-0285-CN-S(P)) | ELISA, WB, FC | Mouse scFv |
| HPAB-0286-CN-S(P) | Human Anti-CEACAM6 Recombinant Antibody; scFv Fragment (HPAB-0286-CN-S(P)) | ELISA, WB, FC | Humanized scFv |
| HPAB-0287-CN-S(P) | Human Anti-CEACAM6 Recombinant Antibody; scFv Fragment (HPAB-0287-CN-S(P)) | ELISA, WB, FC | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0283-CN-F(E) | Human Anti-CEACAM6 Recombinant Antibody; Fab Fragment (HPAB-0283-CN-F(E)) | ELISA, WB, FC | Human Fab |
| HPAB-0284-CN-F(E) | Mouse Anti-CEACAM6 Recombinant Antibody; Fab Fragment (HPAB-0284-CN-F(E)) | ELISA, WB, FC | Mouse Fab |
| HPAB-0285-CN-F(E) | Mouse Anti-CEACAM6 Recombinant Antibody; Fab Fragment (HPAB-0285-CN-F(E)) | ELISA, WB, FC | Mouse Fab |
| HPAB-0286-CN-F(E) | Human Anti-CEACAM6 Recombinant Antibody; Fab Fragment (HPAB-0286-CN-F(E)) | ELISA, WB, FC | Humanized Fab |
| HPAB-0287-CN-F(E) | Human Anti-CEACAM6 Recombinant Antibody; Fab Fragment (HPAB-0287-CN-F(E)) | ELISA, WB, FC | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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