Mouse Anti-CEACAM6 scFv-Fc Chimera (VS-0325-FY179)
CAT#: VS-0325-FY179
This is a monoclonal antibody targeting CEACAM6, a cell adhesion receptor overexpressed in pancreatic ductal adenocarcinoma (PDA) and other cancers. The antibody is designed to inhibit CEACAM6 function, which is implicated in anoikis resistance and tumor invasiveness. Preclinical studies have shown that the antibody has anti-PDA activity in an orthotopic mouse model.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human duodenum
Immunohistochemical staining of human duodenum shows strong cytoplasmic positivity in a subset of leukocytes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11041/ihc_selected.jpg
Normal Tissue
Figure 2 High expression in lung.
Macrophages Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11041/27139_A_3_4.jpg
Normal Tissue
Figure 3 Colon
Enterocytes - Microvilli Staining: Medium Intensity: Moderate Mucosal lymphoid cells Staining: Medium Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11041/27139_A_9_3.jpg
Normal Tissue
Figure 4 Lymph node
Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11041/27139_A_8_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enriched (OE19)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000086548-CEACAM6
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Specificity
- Human CEACAM6
- Species Reactivity
- Human
- Applications
- Western Blot, Immunohistochemistry
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Carcinoembryonic Antigen Related Cell Adhesion Molecule 6; Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 (Non-Specific Cross Reacting Antigen); Normal Cross-Reacting Antigen; NCA; Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6; Non-Specific Crossreacting Antigen
- Gene ID
- 4680
- UniProt ID
- P40199
- Long Name
- Carcinoembryonic Antigen Related Cell Adhesion Molecule 6
- Cellular Localization
- Cell membrane; Cell surface
- Post Translation Modifications
- Glycosylated.
Glycosylation at Asn104, Asn111, Asn115, Asn152, Asn173, Asn197, Asn224, Asn256, Asn274, Asn288, Asn292, and Asn309
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 16 sites, 6 N-linked glycans (3 sites), 1 O-linked glycan (2 sites)
- Protein Refseq
- XP_011525292.1; XP_054177043.1; NP_002474.4
- Function
- Cell surface glycoprotein that plays a role in cell adhesion and tumor progression. Intercellular adhesion occurs in a calcium- and fibronectin-independent manner. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8. Heterophilic interaction with CEACAM8 oCcurs in activated neutrophils. Plays a role in neutrophil adhesion to cytokine-activated endothelial cells.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
See other products for "CEACAM6"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-042 | Recombinant Anti-Human CEACAM6 VHH Single Domain Antibody | ELISA, IHC, FC, FuncS | Llama VHH |
| TAB-004LC-VHH | Anti-Human CEACAM6 Recombinant Antibody (TAB-004LC-VHH) | ELISA, WB, FC, Inhib, FuncS, ICC, SPR | Single domain antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-444LC-F(E) | Anti-Human CEACAM6 Recombinant Antibody Fab Fragment (TAB-444LC-F(E)) | IHC, ELISA, FC, WB | Humanized antibody |
| TAB-446LC-F(E) | Human Anti-CEACAM6 Recombinant Antibody; Fab Fragment (TAB-446LC-F(E)) | WB, IHC | Humanized Fab |
| TAB-447LC-F(E) | Human Anti-CEACAM6 Recombinant Antibody; Fab Fragment (TAB-447LC-F(E)) | WB, IHC | Humanized Fab |
| TAB-448LC-F(E) | Human Anti-CEACAM6 Recombinant Antibody; Fab Fragment (TAB-448LC-F(E)) | WB, IHC | Humanized Fab |
| TAB-449LC-F(E) | Human Anti-CEACAM6 Recombinant Antibody; Fab Fragment (TAB-449LC-F(E)) | WB, IHC | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-445LC-F(E) | Mouse Anti-CEACAM6 Recombinant Antibody; Fab Fragment (TAB-445LC-F(E)) | ELISA, FC | Mouse Fab |
| TAB-477MZ | Mouse Anti-CEACAM6 Recombinant Antibody (TAB-477MZ) | ELISA, FuncS | Mouse IgG |
| TAB-478MZ | Mouse Anti-CEACAM6 Recombinant Antibody (TAB-478MZ) | ELISA | Mouse IgG |
| TAB-477MZ-S(P) | Mouse Anti-CEACAM6 Recombinant Antibody; scFv Fragment (TAB-477MZ-S(P)) | ELISA | Mouse scFv |
| TAB-478MZ-S(P) | Mouse Anti-CEACAM6 Recombinant Antibody; scFv Fragment (TAB-478MZ-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0650 | Hi-Affi™ Rabbit Anti-CEACAM6 Recombinant Antibody (clone DS650AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0283-CN | Human Anti-CEACAM6 Recombinant Antibody (HPAB-0283-CN) | ELISA, WB, FC | Human IgG2, κ |
| HPAB-0284-CN | Mouse Anti-CEACAM6 Recombinant Antibody (HPAB-0284-CN) | ELISA, WB, FC | Mouse IgG1 |
| HPAB-0285-CN | Mouse Anti-CEACAM6 Recombinant Antibody (HPAB-0285-CN) | ELISA, WB, FC | Mouse IgG1 |
| HPAB-0286-CN | Human Anti-CEACAM6 Recombinant Antibody (HPAB-0286-CN) | ELISA, WB, FC | Humanized IgG2, κ |
| HPAB-0287-CN | Human Anti-CEACAM6 Recombinant Antibody (HPAB-0287-CN) | ELISA, WB, FC | Humanized IgG2, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0283-CN-S(P) | Human Anti-CEACAM6 Recombinant Antibody; scFv Fragment (HPAB-0283-CN-S(P)) | ELISA, WB, FC | Human scFv |
| HPAB-0284-CN-S(P) | Mouse Anti-CEACAM6 Recombinant Antibody; scFv Fragment (HPAB-0284-CN-S(P)) | ELISA, WB, FC | Mouse scFv |
| HPAB-0285-CN-S(P) | Mouse Anti-CEACAM6 Recombinant Antibody; scFv Fragment (HPAB-0285-CN-S(P)) | ELISA, WB, FC | Mouse scFv |
| HPAB-0286-CN-S(P) | Human Anti-CEACAM6 Recombinant Antibody; scFv Fragment (HPAB-0286-CN-S(P)) | ELISA, WB, FC | Humanized scFv |
| HPAB-0287-CN-S(P) | Human Anti-CEACAM6 Recombinant Antibody; scFv Fragment (HPAB-0287-CN-S(P)) | ELISA, WB, FC | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0283-CN-F(E) | Human Anti-CEACAM6 Recombinant Antibody; Fab Fragment (HPAB-0283-CN-F(E)) | ELISA, WB, FC | Human Fab |
| HPAB-0284-CN-F(E) | Mouse Anti-CEACAM6 Recombinant Antibody; Fab Fragment (HPAB-0284-CN-F(E)) | ELISA, WB, FC | Mouse Fab |
| HPAB-0285-CN-F(E) | Mouse Anti-CEACAM6 Recombinant Antibody; Fab Fragment (HPAB-0285-CN-F(E)) | ELISA, WB, FC | Mouse Fab |
| HPAB-0286-CN-F(E) | Human Anti-CEACAM6 Recombinant Antibody; Fab Fragment (HPAB-0286-CN-F(E)) | ELISA, WB, FC | Humanized Fab |
| HPAB-0287-CN-F(E) | Human Anti-CEACAM6 Recombinant Antibody; Fab Fragment (HPAB-0287-CN-F(E)) | ELISA, WB, FC | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY62 | AbPlus™ Anti-CEACAM6 Magnetic Beads (VS-0424-XY62) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC147 | Recombinant Anti-CEACAM6 Vesicular Antibody, EV Displayed (VS-0425-YC147) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1357 | Anti-CEACAM6 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1358 | Anti-Mouse CEACAM6 Immunohistochemistry Kit | IHC |
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