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    CEACAM6

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    For Research Use Only. Not For Clinical Use.


    Background

    This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014]
    CEACAM6
    Protein class

    Cancer-related genes, CD markers

    Predicted location

    Intracellular, Membrane (different isoforms)

    Single cell type specificity

    Cell type enhanced (Alveolar cells type 1, Distal enterocytes, Paneth cells, Club cells, Urothelial cells)

    Immune cell specificity

    Immune cell enhanced (neutrophil)

    Cell line specificity

    Cell line enriched (OE19)

    Interaction

    Homodimer; homodimerizes via its Ig-like V-type domain. Heterodimer with CEACAM8; heterodimerizes via its Ig-like V-type domain.

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