Afuco™ Anti-Human CSF3R ADCC Recombinant Antibody, ADCC Enhanced (CAT#: AFC-181CL)
Anti-CSF3R ADCC Enhanced Antibody is an ADCC enhanced antibody produced by our Afuco™ platform. This is a fully human antibody that binds to the G-CSFR, and neutralises the activity of G-CSF in various in vitro assays. It inhibits the G-CSF mediated expression of CXCR1 and CXCR2 on neutrophils which correlates with reduced migratory potential to various chemo-attractants. In vivo NHP studies demonstrate that administration of It is well tolerated and does not result in neutropenia supporting the development of this antibody for indications where neutrophils contribute to the disease pathogenesis.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Cerebral cortex
(Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17116/37869_B_9_5.jpg
(Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17116/37869_B_9_5.jpg
Figure 2 Testis
(Leydig cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17116/37869_A_6_6.jpg
(Leydig cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17116/37869_A_6_6.jpg
Figure 3 Placenta
(Syncytiotrophoblasts - cell body
Staining:High
Intensity: Strong
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17116/37869_A_1_7.jpg
(Syncytiotrophoblasts - cell body
Staining:High
Intensity: Strong
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17116/37869_A_1_7.jpg
Figure 4 RNA cell line category: Group enriched (BEWO, NB-4, THP-1, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000119535-CSF3R
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000119535-CSF3R
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Inflammatory Diseases
Product Property
- Purity
- >95% (SDS-PAGE)
- Storage
- ≤1 year at -20°C.
Target
- Alternative Names
- CD114; GCSFR; CSF3R; colony stimulating factor 3 receptor (granulocyte)
- Gene ID
- 1441
- UniProt ID
- Q99062
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Single Domain Antibody Products
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Rabbit Monoclonal Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-722-sdAb | Recombinant Anti-Human CSF3R VHH Single Domain Antibody | IHC, ICC, FC, FA, FUNC | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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