Mouse Anti-Dabigatran Recombinant Antibody (clone 15C9) (CAT#: PABZ-167)
Recombinant Mouse Antibody (15C9) is capable of binding to Dabigatran, expressed in Chinese Hamster Ovary cells (CHO). The dabigatran binding site of the antibody is located in a concave region at the interface of the variable domains.
Specific Inquiry
Figure 1 aDabi-Fab binds to dabigatran and reverses its effect in vitro.
(B) Immobilized mouse antibodies were analyzed for binding to a hapten-peroxidase conjugate, which was competed off by increasing concentrations of soluble dabigatran. As a representative example, 2 dabigatran-specific antibodies together with a negative control, mAb, are shown. Complete inhibition is observed at a dabigatran time interval. Each PRP sample was incubated with 5mM CaCl2 and 3 mg/mL aDabi-Fab (final concentration). SFLLRN (1-5mM final concentration, LOXO [1mM], Dossenheim, Germany) was used as a positive control.
Schiele, F., van Ryn, J., Newsome, C., Sepulveda, E., Park, J., Nar, H., & Litzenburger, T. (2013). A specific antidote for dabigatran: functional and structural characterization. Blood, blood-2012.
Figure 2 Affinities of parental mouse Fab 15c9 and humanized aDabi-Fab
Schiele, F., van Ryn, J., Newsome, C., Sepulveda, E., Park, J., Nar, H., & Litzenburger, T. (2013). A specific antidote for dabigatran: functional and structural characterization. Blood, blood-2012.
Specifications
- Immunogen
- Dabigatran etexilate
- Host Species
- Mouse
- Type
- Mouse IgG
- Clone
- 15C9
- Applications
- ELISA, Neut
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The antibody 15C9 has been reported in applications of Enzyme-linked Immunosorbent Assay, Neutralization. It's recommended that the optimal antibody concentration, dilution, incubition time etc. are best to be carefully titrated in specific assays.
Target
- Alternative Names
- Dabigatran; Pradaxa; Prazaxa; Dabigatran etexilate
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H40 | Anti-Dabigatran Recombinant Antibody (Idarucizumab) | IP, IF, FuncS, FC, Neut, ELISA, IHC | Fab - G1 - kappa |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBZ-167 | Mouse Anti-Dabigatran Recombinant Antibody (clone 15C9); Fab Fragment | ELISA, Neut | Mouse Fab |
| HPAB-1507-FY-F(E) | Mouse Anti-Dabigatran Recombinant Antibody; Fab Fragment (HPAB-1507-FY-F(E)) | Neut, ELISA | Mouse Fab |
| HPAB-1508-FY-F(E) | Mouse Anti-Dabigatran Recombinant Antibody; Fab Fragment (HPAB-1508-FY-F(E)) | Neut, ELISA | Mouse Fab |
| HPAB-1509-FY-F(E) | Mouse Anti-Dabigatran Recombinant Antibody; Fab Fragment (HPAB-1509-FY-F(E)) | Neut, ELISA | Mouse Fab |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBZ-167 | Mouse Anti-Dabigatran Recombinant Antibody (clone 15C9); scFv Fragment | ELISA, Neut | Mouse scFv |
| HPAB-1507-FY-S(P) | Mouse Anti-Dabigatran Recombinant Antibody; scFv Fragment (HPAB-1507-FY-S(P)) | Neut, ELISA | Mouse scFv |
| HPAB-1508-FY-S(P) | Mouse Anti-Dabigatran Recombinant Antibody; scFv Fragment (HPAB-1508-FY-S(P)) | Neut, ELISA | Mouse scFv |
| HPAB-1509-FY-S(P) | Mouse Anti-Dabigatran Recombinant Antibody; scFv Fragment (HPAB-1509-FY-S(P)) | Neut, ELISA | Mouse scFv |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1507-FY | Human Anti-Dabigatran Recombinant Antibody (HPAB-1507-FY) | Neut, ELISA | Chimeric (mouse/human) IgG |
| HPAB-1508-FY | Human Anti-Dabigatran Recombinant Antibody (HPAB-1508-FY) | Neut, ELISA | Chimeric (mouse/human) IgG |
| HPAB-1509-FY | Human Anti-Dabigatran Recombinant Antibody (HPAB-1509-FY) | Neut, ELISA | Chimeric (mouse/human) IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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