Afuco™ Anti-Human FGB ADCC Recombinant Antibody, ADCC Enhanced
CAT#: AFC-264CL
Anti-FGB ADCC Enhanced Antibody is an ADCC enhanced antibody produced by our Afuco™ platform. This is an anti-fibrin chimeric antibody that reacts with fibrin only, and not fibrinogen, and then attached an anticancer agent (ACA) to the antibody. Thus, the immunoconjugate did not create an immune complex in the blood stream and was selectively accumulated to fibrin clots in the tumor stroma to create a scaffold, from which effective sustained release of the ACA occurred. This new cancer stroma-targeting therapy may result in an increased duration of drug exposure and be a highly effective new therapy, particularly for refractory, stroma-rich cancers.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line Hep G2
Immunofluorescent staining of human cell line Hep G2 shows localization to endoplasmic reticulum.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1900/1293_G5_6_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1901/6361_B_7_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1901/6361_A_7_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1900/6492_A_8_4.jpg
Normal Tissue
Figure 5 Testis
Leydig cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1900/6492_A_6_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enriched (Hep G2)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000171564-FGB
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Specifications
- Host Species
- Chimeric
- Derivation
- Chimeric
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Cancer
Product Property
- Purity
- >90% assessed by SDS-PAGE
- Storage
- Store at -20°C. Avoid multiple freeze/thaw cycles.
Target
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "FGB"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2186z | Mouse Anti-FGB Recombinant Antibody (clone 5B1) | WB, ELISA | Mouse IgG1 |
| MOB-1072MZ | Recombinant Mouse Anti-Human FGB Antibody (clone 2G0) | ELISA | Mouse antibody |
| ZG-0346J | Mouse Anti-FGB Recombinant Antibody (ZG-0346J) | WB, ELISA | Mouse IgG |
| VS3-QX427 | Mouse Anti-FGB Recombinant Antibody (clone 1F9) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
| VS7-HM943 | Mouse Anti-FGB Recombinant Antibody (clone CBL281HM) | WB, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0205MZ | Chicken Anti-Fibrinogen Polyclonal IgY | Indirect ELISA, WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1289 | Hi-Affi™ Rabbit Anti-FGB Recombinant Antibody (clone DS1289AB) | ICC, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0384-YJ-S(P) | Mouse Anti-FGB Recombinant Antibody; scFv Fragment (HPAB-0384-YJ-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0384-YJ-F(E) | Mouse Anti-FGB Recombinant Antibody; Fab Fragment (HPAB-0384-YJ-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY832 | Anti-FGB Immunohistochemistry Kit | IHC |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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