Afuco™ Anti-Human GAP43 ADCC Recombinant Antibody, ADCC Enhanced (CAT#: AFC-286CL)
Anti-GAP43 ADCC Enhanced Antibody is an ADCC enhanced antibody produced by our Afuco™ platform. The antibodies to the growth-associated protein, GAP-43, introduced intracellularly using a lipid carrier, blocked the differentiation induced by dbcAMP. Antibodies to GAP43, at a low concentration, blocked neurite out-growth induced by serum withdrawal when cells were grown on a relatively unadhesive substrate.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line SH-SY5Y
(Immunofluorescent staining of human cell line SH-SY5Y shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13392/1510_B4_2_selected.jpg
(Immunofluorescent staining of human cell line SH-SY5Y shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13392/1510_B4_2_selected.jpg
Figure 2 Colon
(Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15600/35117_A_8_3.jpg
(Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15600/35117_A_8_3.jpg
Figure 3 High expression in cerebral cortex
(Endothelial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear Glial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15600/35117_B_9_5.jpg
(Endothelial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear Glial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15600/35117_B_9_5.jpg
Figure 4 RNA cell line category: Cell line enhanced (AF22, NTERA-2, SCLC-21H, SH-SY5Y, U-87 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000172020-GAP43
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000172020-GAP43
Specifications
- Host Species
- Chimeric human/mouse
- Type
- ADCC enhanced antibody
- Species Reactivity
- Mouse
- Related Disease
- Nervous System Diseases
Product Property
- Purity
- 90–95% (SDS-PAGE)
- Storage
- ≤1 year at -20°C.
Target
- Alternative Names
- GAP43; growth associated protein 43; B-50; PP46; neuromodulin; protein F1; neural phosphoprotein B-50; growth-associated protein 43; axonal membrane protein GAP-43; calmodulin-binding protein P-57; nerve growth-related peptide GAP43; neuron growth-associated protein 43
- Gene ID
- 2596
- UniProt ID
- P17677
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0698MZ | Chicken Anti-Gap43 Polyclonal IgY | ICC/IF, IHC, WB | Chicken antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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