anti-HIV immunotoxin G49 (IgG)-Gel
CAT#: AGTO-L059G
This immunotoxin was achieved by conjugating/fusing the Anti-HIV monoclonal antibody to gelonin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to cells infected with HIV. Once bind, the toxin enters cells by receptor-mediated endocytosis, then gelonin inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treatment of AIDS.
Specifications
- Host Species
- Mouse
- Species Reactivity
- HIV
- Clone
- G49
- Molecule Class
- L kappa; IgG1-Gel
- Toxin Description
- Gelonin is a glycoprotein (M.W. approximately 29-30, 000 Kd) purified from the seeds of Gelonium multiforum and belongs to a class of potent ribosomal-inactivating plant toxins. Gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- AIDS
Target
- Alternative Names
- HIV; human immunodeficiency virus; ADIS; Acquired Immune Deficiency Syndrome; Gelonin; Gel
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L021G | CD4-Gel immunotoxin | Cytotoxicity assay, Functional assay | |
| AGTO-L021R | CD4-RTA immunotoxin | Cytotoxicity assay, Functional assay | |
| AGTO-L059R | anti-HIV immunotoxin G49 (IgG)-RTA | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-383 | Mouse Anti-HIV Recombinant Antibody (clone YZ18); scFv Fragment | Neut, FuncS | Mouse scFv |
| HPAB-0182-WJ-S(P) | Human Anti-HIV Recombinant Antibody; scFv Fragment (HPAB-0182-WJ-S(P)) | ELISA, FC | Human scFv |
| HPAB-0825-FY-F(E) | Human Anti-HIV Recombinant Antibody; Fab Fragment (HPAB-0825-FY-F(E)) | Neut | Human Fab |
| HPAB-0925WJ-S(P) | Mouse Anti-HIV Recombinant Antibody (clone AB081); scFv Fragment | ELISA | Mouse scFv |
| HPAB-0926WJ-S(P) | Mouse Anti-HIV Recombinant Antibody (clone AB083); scFv Fragment | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-383 | Mouse Anti-HIV Recombinant Antibody (clone YZ18); Fab Fragment | Neut, FuncS | Mouse Fab |
| HPAB-0825-FY-S(P) | Human Anti-HIV Recombinant Antibody; scFv Fragment (HPAB-0825-FY-S(P)) | Neut | Human scFv |
| HPAB-0925WJ-F(E) | Mouse Anti-HIV Recombinant Antibody (clone AB081); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0926WJ-F(E) | Mouse Anti-HIV Recombinant Antibody (clone AB083); Fab Fragment | ELISA | Mouse Fab |
| HPAB-1725-FY-S(P) | Mouse Anti-HIV Recombinant Antibody; scFv Fragment (HPAB-1725-FY-S(P)) | DB, Inhib | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0182-WJ | Human Anti-HIV Recombinant Antibody (HPAB-0182-WJ) | ELISA, FC | Humanized IgG, λ |
| HPAB-0925WJ | Mouse Anti-HIV Recombinant Antibody (clone AB081) | ELISA | Mouse IgG |
| HPAB-0926WJ | Mouse Anti-HIV Recombinant Antibody (clone AB083) | ELISA | Mouse IgG |
| HPAB-0927WJ | Mouse Anti-HIV Recombinant Antibody (clone AB085) | ELISA | Mouse IgG |
| HPAB-1725-FY | Mouse Anti-HIV Recombinant Antibody (HPAB-1725-FY) | DB, Inhib | Mouse IgG |
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