anti-HIV immunotoxin G49 (IgG)-Gel (CAT#: AGTO-L059G)
This immunotoxin was achieved by conjugating/fusing the Anti-HIV monoclonal antibody to gelonin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to cells infected with HIV. Once bind, the toxin enters cells by receptor-mediated endocytosis, then gelonin inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treatment of AIDS.
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Specifications
- Host Species
- Mouse
- Species Reactivity
- HIV
- Clone
- G49
- Molecule Class
- L kappa; IgG1-Gel
- Toxin Description
- Gelonin is a glycoprotein (M.W. approximately 29-30, 000 Kd) purified from the seeds of Gelonium multiforum and belongs to a class of potent ribosomal-inactivating plant toxins. Gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- AIDS
Target
- Alternative Names
- HIV; human immunodeficiency virus; ADIS; Acquired Immune Deficiency Syndrome; Gelonin; Gel
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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| MHH-466 | Recombinant Human Anti-HIV Antibody | RIA, ELISA, FuncS | IgG |
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| HPAB-1194LY | Human Anti-HIV Recombinant Antibody (HPAB-1194LY) | Neut, ELISA | Human IgG |
| HPAB-0825-FY | Human Anti-HIV Recombinant Antibody (HPAB-0825-FY) | Neut | Human IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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