CD4-RTA immunotoxin
CAT#: AGTO-L021R
This immunotoxin was achieved by conjugating/fusing the CD4 to ricin toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to cells infected with HIV. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of AIDS.
Specifications
- Host Species
- Human
- Species Reactivity
- HIV
- Molecule Class
- CD4-RTA
- Toxin Description
- Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- AIDS
Target
- Alternative Names
- HIV; human immunodeficiency virus; ADIS; Deglycosylated ricin A chain; Ricin A chain; Ricin A; Ricin; RTA; RT; RA; dgRTA; dgRA; dgA
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
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COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-466 | Recombinant Human Anti-HIV Antibody | RIA, ELISA, FuncS | IgG |
| PABL-383 | Mouse Anti-HIV Recombinant Antibody (clone YZ18) | WB, Neut, FuncS | Mouse IgG |
| HPAB-0182-WJ | Human Anti-HIV Recombinant Antibody (HPAB-0182-WJ) | ELISA, FC | Humanized IgG, λ |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L021G | CD4-Gel immunotoxin | Cytotoxicity assay, Functional assay | |
| AGTO-L059G | anti-HIV immunotoxin G49 (IgG)-Gel | Cytotoxicity assay, Functional assay | |
| AGTO-L059R | anti-HIV immunotoxin G49 (IgG)-RTA | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-383 | Mouse Anti-HIV Recombinant Antibody (clone YZ18); scFv Fragment | Neut, FuncS | Mouse scFv |
| HPAB-0825-FY-F(E) | Human Anti-HIV Recombinant Antibody; Fab Fragment (HPAB-0825-FY-F(E)) | Neut | Human Fab |
| HPAB-0925WJ-S(P) | Mouse Anti-HIV Recombinant Antibody (clone AB081); scFv Fragment | ELISA | Mouse scFv |
| HPAB-0926WJ-S(P) | Mouse Anti-HIV Recombinant Antibody (clone AB083); scFv Fragment | ELISA | Mouse scFv |
| HPAB-0927WJ-S(P) | Mouse Anti-HIV Recombinant Antibody (clone AB085); scFv Fragment | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-383 | Mouse Anti-HIV Recombinant Antibody (clone YZ18); Fab Fragment | Neut, FuncS | Mouse Fab |
| HPAB-2936LY-F(E) | Human Anti-HIV Recombinant Antibody; Fab Fragment (HPAB-2936LY-F(E)) | ELISA | Humanized Fab |
| HPAB-2937LY-F(E) | Human Anti-HIV Recombinant Antibody; Fab Fragment (HPAB-2937LY-F(E)) | ELISA | Humanized Fab |
| HPAB-2938LY-F(E) | Human Anti-HIV Recombinant Antibody; Fab Fragment (HPAB-2938LY-F(E)) | ELISA | Humanized Fab |
| HPAB-2939LY-F(E) | Human Anti-HIV Recombinant Antibody; Fab Fragment (HPAB-2939LY-F(E)) | ELISA | Humanized Fab |
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