Recombinant Human Anti-HMPV Antibody (DS7) (CAT#: PABX-106)

Anti-HMPV antibody is a Human antibody of IgG class that binds to an HMPV. This antibody is shows subnanomolar affinity and is highly protective in vivo. It developed From a human antibody phage display library.


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Figure 1 Light-microscopic and immunofluorescent images of hMPV-infected LLC-MK2 cell monolayers stained with human anti-hMPV F Fab and AlexaFluor568-conjugated goat anti-human IgG.

Figure 1 Light-microscopic and immunofluorescent images of hMPV-infected LLC-MK2 cell monolayers stained with human anti-hMPV F Fab and AlexaFluor568-conjugated goat anti-human IgG.

(A and B) Fab ACN044; (C and D) Fab DS7. Magnification, × 20.

Williams, J. V., Chen, Z., Cseke, G., Wright, D. W., Keefer, C. J., Tollefson, S. J., ... & Burton, D. R. (2007). A recombinant human monoclonal antibody to human metapneumovirus fusion protein that neutralizes virus in vitro and is effective therapeutically in vivo. Journal of virology, 81(15), 8315-8324.

Figure 2 SPR analysis of DS7 Fab.

Figure 2 SPR analysis of DS7 Fab.

(A) Association-dissociation curves of decreasing concentrations of DS7 against immobilized hMPV FTM protein. Palivizumab (RSV F-specific MAb) was used as an irrelevant control. (B) Association-dissociation curves of DS7 at 100 nM against immobilized hMPV FTM protein and RSV FTM protein.

Williams, J. V., Chen, Z., Cseke, G., Wright, D. W., Keefer, C. J., Tollefson, S. J., ... & Burton, D. R. (2007). A recombinant human monoclonal antibody to human metapneumovirus fusion protein that neutralizes virus in vitro and is effective therapeutically in vivo. Journal of virology, 81(15), 8315-8324.


Specifications

  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Host Species
  • Human
  • Derivation
  • Human
  • Type
  • IgG
  • Specificity
  • Tested positive against native HMPV
  • Species Reactivity
  • Human metapneumovirus
  • Clone
  • DS7
  • Applications
  • WB 1:1000-1:5000
    ELISA 1:3000-1:15000
    FuncS (assay-depended)

Product Property

  • Purity
  • >95% by SDS-PAGE and HPLC analysis
  • Storage
  • Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.

Applications

  • Application Notes
  • Assay-depended

Target

  • Alternative Names
  • Human metapneumovirus; hMPV

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone DS7"

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Recombinant Antibody

Mouse Antibody

CAT Product Name Application Type
PABX-106-S (P) Recombinant Human Anti-HMPV Antibody scFv Fragment (DS7) ELISA, Neut, FuncS scFv

Human Antibody

CAT Product Name Application Type
PABX-106-F (E) Recombinant Human Anti-HMPV Antibody Fab Fragment (DS7) ELISA, Neut, FuncS Fab

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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