Anti-IAV NP Intrabody [(D-Arg)9] (IAB-B040(A))

Recombinant anti-IAV NP intrabody linked to (D-Arg)9 works within cells and binds specifically to IAV NP, expressed in E. coli cells. Anti-nucleoprotein intrabodies changed their cellular distribution in association with the viral nucleoprotein.      

Influenza A virus nucleoprotein
Cell Penetrating Peptide
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
Species Reactivity
Formats of immunological tests: Western blot; Neutralization; Functional studies
Alternative Names
IAV NP; Influenza A virus nucleoprotein; Common flu NP; Influenza A virus NP; NP; Nucleocapsid protein; Nucleoprotein; Protein N

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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