Recombinant Mouse Antibody (MN14C11. 6) is capable of binding to N. meningitidis P1. 7 peptide, expressed in Chinese Hamster Ovary cells (CHO).
Figure 1 Infant rat infection model
Reactivity of one P1.7 (MN14C11.6) and three P1.16 (MN5C11G, 62D12-8 and MN12H2) specific monoclonal antibodies to isogenic P1.16 strains in (a) whole-cell EIA and (b) bactericidal activity (BCA) assay. The limits of detection, 1:10 000 for whole-cell EIA and 1:50 for BCA assay, are indicated by solid lines. Strains: (n), P1.7,16a; (n), P1.7,16b; (n), P1.7,16c; (n), P1.7,16d.
Toropainen, M., Saarinen, L., van der Ley, P., Kuipers, B., & Käyhty, H. (2001). Murine monoclonal antibodies to PorA of Neisseria meningitidis show reduced protective activity in vivo against B: 15: P1. 7, 16 subtype variants in an infant rat infection model. Microbial pathogenesis, 30(3), 139-148.
Figure 2 Western blots with isogenic target strains derived from H44/76 (B: 15:P1.7,16)
Immunoblots were incubated with specific PorA MAbs, i.e., MN14C11.6, α-P1.7 (a), MN5C11G, α-P1.16 (b), and MN33H7.6, α-loop 5 (c). The numbers of the lanes correspond to the numbers of the strains as listed in Table 2. The arrow in each panel indicates the position of the original PorA P1.7,16.
van der Voort, E. R., Van der Ley, P., Van der Biezen, J., George, S., Tunnela, O., Van Dijken, H., ... & Poolman, J. (1996). Specificity of human bactericidal antibodies against PorA P1. 7, 16 induced with a hexavalent meningococcal outer membrane vesicle vaccine. Infection and immunity, 64(7), 2745-2751.
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• Confirmed specificity
• High repeatability
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CAT | Product Name | Application | Type |
---|---|---|---|
PABW-091 | Recombinant Mouse Anti-N. meningitidis PorA Antibody (MN12H2) | WB, ELISA | IgG |
PABC-092 | Recombinant Mouse Anti-N. meningitidis porA Antibody (MN20B9.34) | WB, ELISA | IgG |
PABW-092 | Recombinant Mouse Anti-N. meningitidis PorA (P1.2) Antibody (MN16C13F4) | ELISA | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBZ-091 | Recombinant Mouse Anti-N. meningitidis P1.7 peptide Antibody Fab Fragment (MN14C11.6) | ELISA | IgG |
PFBW-091 | Recombinant Mouse Anti-N. meningitidis PorA Antibody Fab Fragment (MN12H2) | WB, ELISA | IgG |
PFBC-092 | Recombinant Mouse Anti-N. meningitidis porA Antibody Fab Fragment (MN20B9.34) | WB, ELISA | IgG |
PFBW-092 | Recombinant Mouse Anti-N. meningitidis PorA (P1.2) Antibody Fab Fragment (MN16C13F4) | ELISA | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBZ-091 | Recombinant Mouse Anti-N. meningitidis P1.7 peptide Antibody scFv Fragment (MN14C11.6) | ELISA | scFv |
PSBW-091 | Recombinant Mouse Anti-N. meningitidis PorA Antibody scFv Fragment (MN12H2) | WB, ELISA | scFv |
PSBC-092 | Recombinant Mouse Anti-N. meningitidis porA Antibody scFv Fragment (MN20B9.34) | WB, ELISA | scFv |
PSBW-092 | Recombinant Mouse Anti-N. meningitidis PorA (P1.2) Antibody scFv Fragment (MN16C13F4) | ELISA | scFv |
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