Anti-NDV P Intrabody [Tat] (IAB-B006(T))
Recombinant anti-NDV P intrabody in fusion with HIV Tat works within cells and is specific for NDV P, expressed in CHO cells.
Specifications
- Immunogen
- Newcastle disease virus phosphoprotein
- Host
- chicken
- Type
- scFv-Tat
- Cell Penetrating Peptide
- TAT
TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
- Species Reactivity
- NDV
- Applications
- Used for immunoassay techniques such as: Enzyme-linked Immunosorbent Assay; Neutralization; Functional studies
Target
- Alternative Names
- NDV P; Newcastle disease virus phosphoprotein
- Entrez Gene ID
- 912269
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
Tel: 1-631-381-2994
Fax: 1-631-207-8356
Email: