Recombinant Human Antibody specifically binds to P. aeruginosa PsL .
Stoner, Sara N., Joshua J. Baty, and Jessica A. Scoffield. "Pseudomonas aeruginosa polysaccharide Psl supports airway microbial community development." The ISME journal 16.7 (2022): 1730-1739.
This study explores the role of Pseudomonas aeruginosa polysaccharide Psl in the development of airway microbial communities, specifically within the context of cystic fibrosis (CF). The research focuses on interactions between P. aeruginosa and Streptococcus salivarius, demonstrating that Psl promotes biofilm formation by S. salivarius. The study employs both in vitro and in vivo models to show that S. salivarius uses a maltose-binding protein, MalE, to interact with Psl, facilitating its incorporation into the CF airway biofilm and potentially contributing to lung stability in CF patients.
Creative Biolabs provided the FITC-conjugated α-Psl antibody (Cat#: MOB-0286MC) used in the immunofluorescence and confocal laser scanning microscopy experiments. This antibody was crucial for visualizing the spatial relationship between Psl and S. salivarius within dual biofilms, allowing researchers to confirm the role of Psl in promoting S. salivarius biofilm formation and understanding the structural changes in the biofilm architecture.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-736 | Recombinant Anti-P. aeruginosa psl Antibody | WB, IP, FuncS | IgG |
MHH-736 | Recombinant Human Anti-P. aeruginosa psl Antibody | WB, RIA, FuncS | IgG |
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# MOB-0286MC, RRID: AB_3111473)
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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