Anti-Human PTGDR2 Recombinant Antibody (19A2) (CAT#: TAB-067MZ)
Recombinant monoclonal antibody to human CRTh2. 19A2 is a mouse monoclonal antibody intended for the prophylaxis and treatment of related disease, such as asthma.
Specific Inquiry
FC
Figure 1 hCRTh2-reactive antibodies 19A2 and 8B1 specifically bind hCRTh2.
Flow cytometry analyses of mouse anti-hCRTh2 Abs 19A2 and 8B1 binding to hCRTh2 expressed on 293 cells but not mock-transfected WT 293 cells.
Huang, T., Hazen, M., Shang, Y., Zhou, M., Wu, X., Yan, D., ... & Shi, Y. (2016). Depletion of major pathogenic cells in asthma by targeting CRTh2. JCI insight, 1(7).
IF
Figure 2 Therapeutic treatment with anti-hCRTh2 19A2 antibodies depletes basophils and eosinophils from lung and inhibits IL4 production in a mouse model of allergic asthma.
Graphs show morphological scoring of eosinophil frequency in lung.
Huang, T., Hazen, M., Shang, Y., Zhou, M., Wu, X., Yan, D., ... & Shi, Y. (2016). Depletion of major pathogenic cells in asthma by targeting CRTh2. JCI insight, 1(7).
Specifications
- Immunogen
- Human CRTh2 DNA in pRK5 vector
- Host Species
- Mouse
- Specificity
- Human
- Species Reactivity
- Cynomolgus
- Clone
- 19A2
- Applications
- FC, IF
- Related Disease
- Asthma
Applications
- Application Notes
- The PTGDR2 antibody has been reported in applications of Flow Cytometry, Immunofluorescence. FC: Anti-CRTh2 Ab concentrations were 20 μg/ml (solid line), 2 μg/ml (dashed line), and 0.2 μg/ml (dotted line); isotype control Ab was 20 μg/ml (tinted histogram).
Target
- Alternative Names
- PTGDR2; prostaglandin D2 receptor 2; DP2; DL1R; CD294; CRTH2; GPR44; G protein-coupled receptor 44; G-protein coupled receptor 44; putative G-protein coupled receptor 44; chemoattractant receptor-homologous molecule expressed on TH2 cells; chemoattractant receptor homologous molecule expressed on T helper type 2 cells
- Gene ID
- 11251
- UniProt ID
- Q9Y5Y4
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Flow Cytometry (FC) related Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2771z | Recombinant Anti-Human PTGDR2 Antibody | WB, FC, FuncS | IgG |
| HPAB-0685YY | Human Anti-PTGDR2 Recombinant Antibody (HPAB-0685YY) | FC, Inhib, Antagonist, ELISA | Humanized IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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