Anti-Human PTGDR2 Recombinant Antibody (19A2) (CAT#: TAB-067MZ)
Recombinant monoclonal antibody to human CRTh2. 19A2 is a mouse monoclonal antibody intended for the prophylaxis and treatment of related disease, such as asthma.
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FC
Figure 1 hCRTh2-reactive antibodies 19A2 and 8B1 specifically bind hCRTh2.
Flow cytometry analyses of mouse anti-hCRTh2 Abs 19A2 and 8B1 binding to hCRTh2 expressed on 293 cells but not mock-transfected WT 293 cells.
Huang, T., Hazen, M., Shang, Y., Zhou, M., Wu, X., Yan, D., ... & Shi, Y. (2016). Depletion of major pathogenic cells in asthma by targeting CRTh2. JCI insight, 1(7).
IF
Figure 2 Therapeutic treatment with anti-hCRTh2 19A2 antibodies depletes basophils and eosinophils from lung and inhibits IL4 production in a mouse model of allergic asthma.
Graphs show morphological scoring of eosinophil frequency in lung.
Huang, T., Hazen, M., Shang, Y., Zhou, M., Wu, X., Yan, D., ... & Shi, Y. (2016). Depletion of major pathogenic cells in asthma by targeting CRTh2. JCI insight, 1(7).
Specifications
- Immunogen
- Human CRTh2 DNA in pRK5 vector
- Host Species
- Mouse
- Specificity
- Human
- Species Reactivity
- Cynomolgus
- Clone
- 19A2
- Applications
- FC, IF
- Related Disease
- Asthma
Applications
- Application Notes
- The PTGDR2 antibody has been reported in applications of Flow Cytometry, Immunofluorescence. FC: Anti-CRTh2 Ab concentrations were 20 μg/ml (solid line), 2 μg/ml (dashed line), and 0.2 μg/ml (dotted line); isotype control Ab was 20 μg/ml (tinted histogram).
Target
- Alternative Names
- PTGDR2; prostaglandin D2 receptor 2; DP2; DL1R; CD294; CRTH2; GPR44; G protein-coupled receptor 44; G-protein coupled receptor 44; putative G-protein coupled receptor 44; chemoattractant receptor-homologous molecule expressed on TH2 cells; chemoattractant receptor homologous molecule expressed on T helper type 2 cells
- Gene ID
- 11251
- UniProt ID
- Q9Y5Y4
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2771z | Recombinant Anti-Human PTGDR2 Antibody | WB, FC, FuncS | IgG |
| HPAB-0685YY | Human Anti-PTGDR2 Recombinant Antibody (HPAB-0685YY) | FC, Inhib, Antagonist, ELISA | Humanized IgG1 |
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