Anti-PTPRZ1 immunotoxin 7E4B11 (IgG)-Sap
CAT#: AGTO-G058S
This immunotoxin was achieved by conjugating/fusing the Anti-PTPRZ1 monoclonal antibody to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of glioblastoma.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line AF22
Immunofluorescent staining of human cell line AF22 shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15103/1783_C5_2_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Glial cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous nuclear
Neuronal cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Neuropil
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15103/168357_B_9_5.jpg
Normal Tissue
Figure 3 Testis
Cells in seminiferous ducts
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15103/168357_A_6_6.jpg
RNA Expression
Figure 4 RNA cell line category: Group enriched (AF22, NTERA-2, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000106278-PTPRZ1/subcellular
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Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Clone
- 7E4B11
- Molecule Class
- IgG-Sap
- Toxin Description
- Saporin is a so-called ribosome inactivating protein (RIP), due to its N-glycosidase activity, from the seeds of Saponaria officinalis (common name: soapwort).Saporin depurinate the ribosomal RNA in a specific position; rendering the large subunit of ribosomes unable to bind the elongation factors. The consequent arrest of protein synthesis is responsible for the cytotoxicity.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Glioblastoma
Target
- Alternative Names
- PTPRZ1; protein tyrosine phosphatase, receptor-type, Z polypeptide 1; PTPZ; HPTPZ; PTP18; PTPRZ; RPTPB; HPTPzeta; PTP-ZETA; RPTPbeta; phosphacan; R-PTP-zeta-2; receptor-type tyrosine-protein phosphatase zeta; receptor-type tyrosine phosphatase beta/zeta; protein-tyrosine phosphatase receptor type Z polypeptide 2; protein tyrosine phosphatase, receptor-type, zeta polypeptide 1; saporin; saporin-6; saporin-S55; SAP
- Gene ID
- 5803
- UniProt ID
- B4DFE7
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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MSDS
COA
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See other products for "PTPRZ1"
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| BRD-0477MZ | Chicken Anti-PTPRZ1 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5884 | Anti-PTPRZ1 Immunohistochemistry Kit | IHC |
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