Anti-PrPC Intrabody [Tat] (IAB-B055(T))

Recombinant anti-PrPC intrabody in fusion with HIV Tat works within cells and specifically reacts with endogenous PrPC, expressed in E. coli cells.      

prion protein
Cell Penetrating Peptide
TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
Species Reactivity
Products can be used for: Coimmunopricipation; Functional studies
Alternative Names
PrPC; prion protein

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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