Recombinant Human Anti-S. aureus Antibody (LTM14)
CAT#: PABX-167
Anti-S. aureus antibody is a Human antibody of IgG class that binds to an S. aureus. It developed From a human scFv phage library.
Published Data
Block
Figure 1 Blocking activity of antibodies against α-hemolysin in human serum samples and in vitro neutralizing activity of LTM14.
Foletti, D., Strop, P., Shaughnessy, L., Hasa-Moreno, A., Casas, M. G., Russell, M., ... & Pons, J. (2013). Mechanism of action and in vivo efficacy of a human-derived antibody against Staphylococcus aureus α-hemolysin. Journal of molecular biology, 425(10), 1641-1654.
Block
Figure 2 LTM14 dose-dependently blocks the lytic activity of α-hemolysin on REs.
Foletti, D., Strop, P., Shaughnessy, L., Hasa-Moreno, A., Casas, M. G., Russell, M., ... & Pons, J. (2013). Mechanism of action and in vivo efficacy of a human-derived antibody against Staphylococcus aureus α-hemolysin. Journal of molecular biology, 425(10), 1641-1654.
FuncS
Figure 3 In vivo efficacy of LTM14 in a mouse model of S. aureus pneumonia, prophylactic antibody administration.
Survival curves for groups of mice dosed with LTM14 (30 mg/kg ip) or vehicle before intranasal challenge with 3.2 x 10⁸ CFU of S. aureus USA300 LAC.
Foletti, D., Strop, P., Shaughnessy, L., Hasa-Moreno, A., Casas, M. G., Russell, M., ... & Pons, J. (2013). Mechanism of action and in vivo efficacy of a human-derived antibody against Staphylococcus aureus α-hemolysin. Journal of molecular biology, 425(10), 1641-1654.
FuncS
Figure 4 In vivo efficacy of LTM14 in a mouse model of S. aureus pneumonia, therapeutic antibody administration and combination with linezolid.
Survival curves for groups of mice dosed with either 30 mg/kg LTM14 or 12 mg/kg linezolid 12 and 18 h after intranasal challenge with 5x 10⁸ CFU of S. aureus USA300 LAC.
Foletti, D., Strop, P., Shaughnessy, L., Hasa-Moreno, A., Casas, M. G., Russell, M., ... & Pons, J. (2013). Mechanism of action and in vivo efficacy of a human-derived antibody against Staphylococcus aureus α-hemolysin. Journal of molecular biology, 425(10), 1641-1654.
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Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Human
- Type
- IgG
- Antibody Isotype
- IgG
- Specificity
- Tested positive against native S. aureus
- Species Reactivity
- Staphylococcus aureus
- Clone
- LTM14
- Applications
- Block, FuncS
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- This antibody has been reported for use in Functional Assay and Blocking. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. should be carefully titrated in specific assays.
Target
- Alternative Names
- S. aureus; Staphylococcus aureus
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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- CAT
- Product Name
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