Anti-S. Epidermidis LTA Recombinant Antibody (Pagibaximab) (CAT#: TAB-H53)
Recombinant Chimeric (human/mouse) antibody to S. epidermidis LTA. Pagibaximab is a chimeric monoclonal antibody for the prevention of staphylococcal sepsis in infants with low birth weight.
Specific Inquiry
ELISA
Figure 1 Plasma anti-LTA antibody concentrations over time by pagibaximab dose group on a semilogarithmic axis.
There were seven patients in the 10-mg/kg dose group with data for six patients included on day 56. There were eight patients in the 30-mg/kg dose group with data for seven patients included on day 42 and data for five patients included on day 56. There were eight patients in the 60-mg/kg dose group with data for seven patients included on day 14, day 28, and day 42 and data for six patients included on day 56. There were eight patients in the 90-mg/kg dose group with data for six patients included on day 56.
Weisman, L. E., Thackray, H. M., Garcia-Prats, J. A., Nesin, M., Schneider, J. H., Fretz, J., ... & Fischer, G. W. (2009). Phase 1/2 double-blind, placebo-controlled, dose escalation, safety, and pharmacokinetic study of pagibaximab (BSYX-A110), an antistaphylococcal monoclonal antibody for the prevention of staphylococcal bloodstream infections, in very-low-birth-weight neonates. Antimicrobial agents and chemotherapy, 53(7), 2879-2886.
ELISA
Figure 2 Pagibaximab mean serum concentration, level versus day after infusion for 90 mg/kg (solid) and 60 mg/kg (dashed) groups.
The horizontal solid line represents 500 μg/mL. The day and serum level of staphylococcal-positive blood culture for placebo, 60, and 90 mg/kg groups are represented by a triangle, diamond, and square, respectively.
Weisman, L. E., Thackray, H. M., Steinhorn, R. H., Walsh, W. F., Lassiter, H. A., Dhanireddy, R., ... & Meissner, H. C. (2011). A randomized study of a monoclonal antibody (pagibaximab) to prevent staphylococcal sepsis. Pediatrics, 128(2), 271-279.
Specifications
- Host Species
- Mouse
- Derivation
- Chimeric (human/mouse)
- Type
- IgG1 - kappa
- Specificity
- Staphylococcus epidermidis lipoteichoic acid [Staphylococcus epidermidis]
- Species Reactivity
- S. epidermidis
- Applications
- ELISA
- CAS
- 595566-61-3
- Generic Name
- pagibaximab
- MW
- 146,072.36 g/mol
- Related Disease
- Staphylococcal sepsis in infants with low birth weight
Product Property
- Purity
- >95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
Applications
- Application Notes
- The S. Epidermidis LTA antibody has been reported in applications of Enzyme-linked Immunosorbent Assay.
ELISA: 10, 30, 50, 90-mg/kg.
Target
- Alternative Names
- pagibaximab;595566-61-3;BSYX-A110;A110;HU96-110;Lipoteichoic acid;LTA;S. epidermidis LTA;Staphylococcus epidermidis lipoteichoic acid
Related Resources
Please refer to Pagibaximab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Pagibaximab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Pagibaximab"
Afuco™ Anti-S. epidermidis LTA ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H53)This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant Chimeric (human/mouse) antibody to S. epidermidis LTA. It is a chimeric monoclonal antibody for the prevention of staphylococcal sepsis in infants with low birth weight.
DrugMonitor™ Anti-Pagibaximab Antibody (VS-1224-YC880)Pagibaximab is a chimeric monoclonal antibody developed to prevent staphylococcal sepsis in low-birth-weight infants. The DrugMonitor™ Anti-Pagibaximab Antibody (VS-1224-YC880) is an anti-drug antibody (ADA) against Pagibaximab. This drug-based antibody is raised in mice immunized with the Pagibaximab. The anti-Pagibaximab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Pagibaximab in samples.
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ADCC Enhanced Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-H53 | Afuco™ Anti-S. epidermidis LTA ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H53) | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
Customer Reviews and Q&As
Customer Review
Q&As
Highly Specific Antibody
Pagibaximab has been a game-changer in my research on Staphylococcus epidermidis. Its specificity for LTA is exceptional, allowing me to precisely detect and quantify this bacterium in mixed cultures. This has significantly improved the accuracy of my results. The antibody performs consistently, and I appreciate the comprehensive datasheet provided by Creative Biolabs. I highly recommend this antibody to anyone studying S. epidermidis.
Versatile Research Tool
Pagibaximab is a versatile antibody that I've used in ELISA, immunofluorescence, and flow cytometry. In all applications, it has performed exceptionally well. Its ability to adapt to different assay formats makes it a cost-effective choice for our lab. The results have been consistent and reliable, aiding significantly in our studies of bacterial pathogenesis.
Effective in ELISA Assays
I've used Pagibaximab in several ELISA assays, and the results have been outstanding. The antibody shows high affinity and provides a strong signal, contributing to the sensitivity of the assay. It's been instrumental in quantifying LTA levels accurately. I would recommend it to anyone looking to improve their ELISA experiments.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-H53, RRID: AB_3112037)
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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