Anti-S. Epidermidis LTA Recombinant Antibody (Pagibaximab)
CAT#: TAB-H53
Recombinant Chimeric (human/mouse) antibody to S. epidermidis LTA. Pagibaximab is a chimeric monoclonal antibody for the prevention of staphylococcal sepsis in infants with low birth weight.
Published Data
ELISA
Figure 1 Plasma anti-LTA antibody concentrations over time by pagibaximab dose group on a semilogarithmic axis.
There were seven patients in the 10-mg/kg dose group with data for six patients included on day 56. There were eight patients in the 30-mg/kg dose group with data for seven patients included on day 42 and data for five patients included on day 56. There were eight patients in the 60-mg/kg dose group with data for seven patients included on day 14, day 28, and day 42 and data for six patients included on day 56. There were eight patients in the 90-mg/kg dose group with data for six patients included on day 56.
Weisman, L. E., Thackray, H. M., Garcia-Prats, J. A., Nesin, M., Schneider, J. H., Fretz, J., ... & Fischer, G. W. (2009). Phase 1/2 double-blind, placebo-controlled, dose escalation, safety, and pharmacokinetic study of pagibaximab (BSYX-A110), an antistaphylococcal monoclonal antibody for the prevention of staphylococcal bloodstream infections, in very-low-birth-weight neonates. Antimicrobial agents and chemotherapy, 53(7), 2879-2886.
ELISA
Figure 2 Pagibaximab mean serum concentration, level versus day after infusion for 90 mg/kg (solid) and 60 mg/kg (dashed) groups.
The horizontal solid line represents 500 μg/mL. The day and serum level of staphylococcal-positive blood culture for placebo, 60, and 90 mg/kg groups are represented by a triangle, diamond, and square, respectively.
Weisman, L. E., Thackray, H. M., Steinhorn, R. H., Walsh, W. F., Lassiter, H. A., Dhanireddy, R., ... & Meissner, H. C. (2011). A randomized study of a monoclonal antibody (pagibaximab) to prevent staphylococcal sepsis. Pediatrics, 128(2), 271-279.
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Specifications
- Host Species
- Mouse
- Derivation
- Chimeric (human/mouse)
- Type
- IgG1 - kappa
- Specificity
- Staphylococcus epidermidis lipoteichoic acid [Staphylococcus epidermidis]
- Species Reactivity
- S. epidermidis
- Applications
- ELISA
- CAS
- 595566-61-3
- Generic Name
- pagibaximab
- MW
- 146,072.36 g/mol
- Related Disease
- Staphylococcal sepsis in infants with low birth weight
Product Property
- Purity
- >95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
Applications
- Application Notes
- The S. Epidermidis LTA antibody has been reported in applications of Enzyme-linked Immunosorbent Assay.
ELISA: 10, 30, 50, 90-mg/kg.
Target
- Alternative Names
- pagibaximab;595566-61-3;BSYX-A110;A110;HU96-110;Lipoteichoic acid;LTA;S. epidermidis LTA;Staphylococcus epidermidis lipoteichoic acid
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Highly Specific Antibody
Pagibaximab has been a game-changer in my research on Staphylococcus epidermidis. Its specificity for LTA is exceptional, allowing me to precisely detect and quantify this bacterium in mixed cultures. This has significantly improved the accuracy of my results. The antibody performs consistently, and I appreciate the comprehensive datasheet provided by Creative Biolabs. I highly recommend this antibody to anyone studying S. epidermidis.
Versatile Research Tool
Pagibaximab is a versatile antibody that I've used in ELISA, immunofluorescence, and flow cytometry. In all applications, it has performed exceptionally well. Its ability to adapt to different assay formats makes it a cost-effective choice for our lab. The results have been consistent and reliable, aiding significantly in our studies of bacterial pathogenesis.
Effective in ELISA Assays
I've used Pagibaximab in several ELISA assays, and the results have been outstanding. The antibody shows high affinity and provides a strong signal, contributing to the sensitivity of the assay. It's been instrumental in quantifying LTA levels accurately. I would recommend it to anyone looking to improve their ELISA experiments.
Q&As
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What is the specificity of the anti-Staphylococcus epidermidis LTA antibody Pagibaximab?
A: Pagibaximab is a monoclonal antibody that specifically targets lipoteichoic acid (LTA) present on the cell surface of Staphylococcus epidermidis. Its high specificity allows researchers to accurately detect and quantify S. epidermidis in various samples without significant cross-reactivity with other bacterial species. This specificity is crucial for studies focusing on S. epidermidis-related infections and biofilm formation.
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Does Pagibaximab exhibit cross-reactivity with other bacterial species?
A: Pagibaximab is designed to have high specificity for S. epidermidis LTA, with minimal cross-reactivity to other bacteria. However, some degree of cross-reactivity may occur with closely related staphylococcal species that share similar LTA structures. It is advisable to include appropriate controls in experiments to account for any potential non-specific binding.
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Does Creative Biolabs offer bulk purchasing options for Pagibaximab?
A: Yes, Creative Biolabs provides bulk purchasing options for Pagibaximab to accommodate larger research projects or institutional needs. Bulk orders may come with customized pricing and packaging. Customers interested in bulk quantities should contact Creative Biolabs' customer service for detailed information regarding availability, pricing, and lead times.
View the frequently asked questions answered by Creative Biolabs Support.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-H53, RRID: AB_3112037)
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Biosimilar Overview
Please refer to Pagibaximab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Pagibaximab.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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See other products for "Pagibaximab"
Afuco™ Anti-S. epidermidis LTA ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H53)This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant Chimeric (human/mouse) antibody to S. epidermidis LTA. It is a chimeric monoclonal antibody for the prevention of staphylococcal sepsis in infants with low birth weight.
DrugMonitor™ Anti-Pagibaximab Antibody (VS-1224-YC880)Pagibaximab is a chimeric monoclonal antibody developed to prevent staphylococcal sepsis in low-birth-weight infants. The DrugMonitor™ Anti-Pagibaximab Antibody (VS-1224-YC880) is an anti-drug antibody (ADA) against Pagibaximab. This drug-based antibody is raised in mice immunized with the Pagibaximab. The anti-Pagibaximab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Pagibaximab in samples.
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| AFC-TAB-H53 | Afuco™ Anti-S. epidermidis LTA ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H53) | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
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