Human Anti-SLC6A6 Recombinant Antibody (HPAB-0012-LS)
CAT#: HPAB-0012-LS
The monoclonal antibody has higher affinity than conventional antibodies and can recognize native SLC6A6 or a polypeptide of an extracellular domain of SLC6A6.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A549
Immunofluorescent staining of human cell line A549 shows localization to cytosol & cell junctions.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15028/1636_E2_9_cr57bed6ae07246_selected.jpg
Normal Tissue
Figure 2 Small intestine
High expression in small intestine
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15028/34643_A_6_2_val_selected.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15028/34643_A_8_3.jpg
Normal Tissue
Figure 4 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15028/34643_A_8_4.jpg
Normal Tissue
Figure 5 Kidney
Collecting ducts Staining: Medium Intensity: Moderate Quantity: 75%-25% Distal tubules Staining: Medium Intensity: Moderate Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15028/34643_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Sertoli cells Staining: Medium Intensity: Moderate Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15028/34643_A_6_6.jpg
Normal Tissue
Figure 7 Placenta
Trophoblastic cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15028/34643_A_2_7.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (HeLa, RPTEC TERT1)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000131389-SLC6A6
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Specifications
- Immunogen
- SLC6A6
- Host Species
- Human
- Type
- Chimeric (mouse/human) IgG
- Specificity
- Human SLC6A6
- Species Reactivity
- Human, Mouse
- Applications
- FC
- Related Disease
- Colon cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Flow Cytometry.
Target
REVIEWS AND Q&AS
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Great Support and Quality
Creative Biolabs' provision of this high-affinity anti-SLC6A6 antibody has supported groundbreaking research in our lab. Its performance in flow cytometry applications stands validated, and the customer support is responsive and knowledgeable.
Exceptional Performance in Flow Cytometry
Utilizing this antibody in flow cytometry has significantly enhanced our cellular analysis. Its specificity allows precise measurements of transporter expression levels, crucial for our ongoing projects in cellular physiology.
Reliable for Metabolic Research
The Human Anti-SLC6A6 Recombinant Antibody has become indispensable in our metabolic disorder studies. Its high affinity for the taurine transporter and excellent specificity ensure robust data, revealing intricate dynamics of amino acid transport.
Q&As
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What is the primary focus of the SLC6A6 antibody in research?
A: The Human Anti-SLC6A6 Recombinant Antibody targets the SLC6A6 protein, also known as the taurine transporter. It is essential for studies focusing on amino acid transport, particularly taurine's role in various physiological processes. This transporter is critical for maintaining taurine homeostasis, aiding research into cardiovascular health, neurology, and metabolic disorders.
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What specific binding capacity does this antibody have?
A: The chimeric antibody has a high binding affinity for SLC6A6, recognizing both the native transporter and its extracellular domain. This specificity is advantageous in detecting and analyzing the transporter's function in various cellular contexts, crucial for studies in cell signaling and transport mechanisms.
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Which cellular locations and tissues express SLC6A6?
A: This transporter is expressed in various tissues, including the small intestine, colon, liver, kidney, and nervous system, suggesting a multifaceted role in nutrient absorption and cellular metabolism. Understanding its distribution is essential for appreciating its physiological significance.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-455CT | Anti-Human SLC6A6 Recombinant Antibody (4B9b) | ELISA, WB, FC | |
| TAB-455CT-S(P) | Anti-Human SLC6A6 Recombinant Antibody scFv Fragment (4B9b) | ELISA, WB, FC | |
| TAB-456CT-S(P) | Anti-Human SLC6A6 Recombinant Antibody scFv Fragment (5H12d ) | ELISA, WB, FC | |
| TAB-455CT-F(E) | Anti-Human SLC6A6 Recombinant Antibody Fab Fragment (4B9b) | ELISA, WB, FC | |
| TAB-456CT-F(E) | Anti-Human SLC6A6 Recombinant Antibody Fab Fragment (5H12d ) | ELISA, WB, FC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0012-LS-F(E) | Human Anti-SLC6A6 Recombinant Antibody Fab Fragment (HPAB-0012-LS-F(E)) | FC | Chimeric (mouse/human) Fab |
| HPAB-0223-YJ-S(P) | Mouse Anti-SLC6A6 Recombinant Antibody; scFv Fragment (HPAB-0223-YJ-S(P)) | ELISA, FC, IHC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0012-LS-S(P) | Mouse Anti-SLC6A6 Recombinant Antibody scFv Fragment (HPAB-0012-LS-S(P)) | FC | Mouse scFv |
| HPAB-0223-YJ-F(E) | Mouse Anti-SLC6A6 Recombinant Antibody; Fab Fragment (HPAB-0223-YJ-F(E)) | ELISA, FC, IHC | Mouse Fab |
| HPAB-0224-YJ-F(E) | Human Anti-SLC6A6 Recombinant Antibody; Fab Fragment (HPAB-0224-YJ-F(E)) | ELISA, FC, IHC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-163CQ | Mouse Anti-Human SLC6A6 Antibody | ELISA, WB, IP, IF | Mouse IgG1 |
| HPAB-0223-YJ | Mouse Anti-SLC6A6 Recombinant Antibody (HPAB-0223-YJ) | IHC, FC, ELISA | Mouse IgG2b, κ |
| HPAB-0224-YJ | Human Anti-SLC6A6 Recombinant Antibody (HPAB-0224-YJ) | ELISA, FC, IHC | Chimeric (mouse/human) IgG1, κ |
| VS-0224-XY121 | Mouse Anti-SLC6A6 Recombinant Antibody (VS-0224-XY121) | ELISA, WB, IF, IP | Mouse IgG1 kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC141 | Recombinant Anti-SLC6A6 Vesicular Antibody, EV Displayed (VS-0425-YC141) | ELISA, FC, Cell-uptake |
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