Recombinant Mouse Anti-Testosterone Antibody (77Fab) (CAT#: PABX-176)
Anti-Testosterone antibody is a Mouse antibody of IgG class that binds to an Testosterone.
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Figure 1 Overlay plot of the subtractive sensograms obtained after sequential injection of the wt 3-C4F5 and 77 Fab fragments over a CM5 sensor chip surface containing immobilized testoserone-3-CMO-BSA.
Overlay plot of the subtractive sensograms obtained after sequential injection of the wt 3-C4F5 and 77 Fab fragments
over a CM5 sensor chip surface containing immobilized testoserone-3-CMO-BSA.
Valjakka, J., Hemminki, A., Niemi, S., Söderlund, H., Takkinen, K., & Rouvinen, J. (2002). Crystal Structure of an in Vitro Affinity-and Specificity-matured Anti-testosterone Fab in Complex with Testosterone IMPROVED AFFINITY RESULTS FROM SMALL STRUCTURAL CHANGES WITHIN THE VARIABLE DOMAINS. Journal of Biological Chemistry, 277(46), 44021-44027.
Figure 2 Structure of the variable domain of 77 Fab in complex with testosterone (blue).
The mutations of the 77 Fab are shown in red. The figure has been drawn by the SETOR program.
Valjakka, J., Hemminki, A., Niemi, S., Söderlund, H., Takkinen, K., & Rouvinen, J. (2002). Crystal Structure of an in Vitro Affinity-and Specificity-matured Anti-testosterone Fab in Complex with Testosterone IMPROVED AFFINITY RESULTS FROM SMALL STRUCTURAL CHANGES WITHIN THE VARIABLE DOMAINS. Journal of Biological Chemistry, 277(46), 44021-44027.
Figure 3 The binding site in the 77 Fab (A) and in the wt Fab (B) structures.
The solvent-accessible surface was produced using the O program.
Valjakka, J., Hemminki, A., Niemi, S., Söderlund, H., Takkinen, K., & Rouvinen, J. (2002). Crystal Structure of an in Vitro Affinity-and Specificity-matured Anti-testosterone Fab in Complex with Testosterone IMPROVED AFFINITY RESULTS FROM SMALL STRUCTURAL CHANGES WITHIN THE VARIABLE DOMAINS. Journal of Biological Chemistry, 277(46), 44021-44027.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- IgG
- Specificity
- Tested positive against native Testosterone
- Clone
- 77Fab
- Applications
- Neut (assay dependent)
FuncS (assay dependent)
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- Assay-depended
Target
- Alternative Names
- Testosterone; (8R,9S,10R,13S,14S,17S)-17-Hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta phenanthren-3-one; Androderm; Delatestryl; testred; TESTOSTERONE; testex; testoderm
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Single Domain Antibody Products
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Anti-Small Molecule Drug Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-100 | Recombinant Anti-human Testosterone VHH Single Domain Antibody | WB, IHC, FC, FuncS | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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