BAFF-DT immunotoxin
CAT#: AGTO-L075D
This immunotoxin was achieved by conjugating/fusing the BAFF to Diphtheriatoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to BCMA expressing B cells. Once bind, the toxin enters cells by receptor-mediated endocytosis, then Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme; -II binding and elongation factor into the eukaryotic cell; the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs; thereby preventing protein synthesis and causes cell death. It was designed for treatment of B cell leukemias.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (Karpas-707, RPMI-8226, U-266/70, U-266/84)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000048462-TNFRSF17
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Specifications
- Host Species
- Human
- Species Reactivity
- Human
- Molecule Class
- BAFF-DT
- Toxin Description
- Diphtheria toxin (Diphtheriatoxin, DT) is a cell toxin produced by diphtheria, is a protein toxin most commonly used in the construction of recombinant immunotoxin. Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme, -II binding and elongation factor into the eukaryotic cell, the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs, thereby preventing protein synthesis and causes cell death.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- B cell leukemias
Target
- Alternative Names
- B cell maturation antigen; B cell maturation factor; B cell maturation protein; B-cell maturation protein; BCM; BCMA; CD269; CD269 antigen; TNFRSF17; TNR17_HUMAN; Tumor necrosis factor receptor superfamily member 17; B cell leukemias; Diphtheria toxin; Diphtheria-toxin; DT; DT388; DT389; DT390; DAB389
- Gene ID
- 608
- UniProt ID
- Q02223
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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COA
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See other products for "BCMA"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L075E | BAFF-PE immunotoxin | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0723-WK197 | Rabbit Anti-BCMA Recombinant Antibody (VS-0723-WK197) | FC, IP | Rabbit IgG |
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