What is the primary application of the BV421-H-2Kb/LCMV gp34-43 MHC Tetramer?

This MHC tetramer is designed for the identification and analysis of antigen-specific CD8 T cells targeting the gp34-43 peptide of LCMV, presented by the H-2Kb MHC class I molecule. It is particularly used in flow cytometry to study immune responses in viral infections.

Can this product be used to monitor immune responses in experimental models?

Yes, it is suitable for tracking T cell responses in mouse models of LCMV infection, helping evaluate the effectiveness of vaccines and treatments targeting viral infections.

BV421-H-2Kb/LCMV gp34-43 (AVYNFATCGI) MHC Tetramer (CAT#: MHC-LC299)

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of LCMV-derived peptide of AVYNFATCGI sequence covering 34-43 and H-2Kb molecule. The pMHC tetramer recognizes mouse CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.

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Custom Production

MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.

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Disclaimer: Please note that the MHC reagents we offered have been produced with strict quality control (including gene sequencing, affinity purification, SDS-PAGE analysis, and verification of biotinylation), but many have not been confirmed to stain or activate specific T cells.

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Datasheet
MSDS
COA

Datasheet

MSDS

Certificate of Analysis Lookup
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Lot Number

Specifications

Allele
H-2Kb

Class
Class I

MHC Species
Mouse

Antigen
LCMV gp34-43

Antigen Species
LCMV

Peptide
AVYNFATCGI

Range
34-43

Conjugate
BV421

Application
FCM

Target

Antigen Introduction
Lymphocytic choriomeningitis (LCM) is a rodent-borne viral infectious disease that presents as aseptic meningitis, encephalitis or meningoencephalitis. Its causative agent is the lymphocytic choriomeningitis virus (LCMV), a member of the family Arenaviridae. The name was coined by Charles Armstrong in 1934.

Alternative Names
LCMV GP1; Lymphocytic choriomeningitis virus Glycoprotein 1

Gene ID
1491875

UniProt ID
P26804

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MHC Tetramers for Virology

CAT	Product Name	Application
MHC-LC284	BV421-H-2Db/LCMV gp33 (KAVYNFATC) MHC Tetramer	FCM
MHC-LC293	PE-H-2Db/LCMV gp276-286 (SGVENPGGYCL) MHC Tetramer	FCM
MHC-LC294	APC-H-2Db/LCMV gp276-286 (SGVENPGGYCL) MHC Tetramer	FCM
MHC-LC760	H-2Db/LCMV GP (KAVYNFATC) MHC Tetramer	FCM
MHC-LC761	H-2Db/LCMV GP (SGVENPGGYCL) MHC Tetramer	FCM

Customer Reviews and Q&As

Customer Review Q&As

Brilliant Signal Clarity for T Cell Analysis

The BV421 fluorescent labeling ensures exceptional signal clarity, enabling precise identification of LCMV-specific T cells. This has significantly improved our ability to perform detailed immune profiling in viral research.

High Sensitivity and Specificity for Detection

As a staple in our lab's toolkit, this tetramer captures nuanced immune responses with high sensitivity, essential for comprehensive research into viral immunology.

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