BV421-H-2Kb/LCMV gp34-43 (AVYNFATCGI) MHC Tetramer
CAT#: MHC-LC299
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of LCMV-derived peptide of AVYNFATCGI sequence covering 34-43 and H-2Kb molecule. The pMHC tetramer recognizes mouse CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Specifications
- Allele
- H-2Kb
- Class
- Class I
- MHC Species
- Mouse
- Antigen
- LCMV gp34-43
- Antigen Species
- LCMV
- Peptide
- AVYNFATCGI
- Range
- 34-43
- Conjugate
- BV421
- Application
- FCM
Target
- Antigen Introduction
- Lymphocytic choriomeningitis (LCM) is a rodent-borne viral infectious disease that presents as aseptic meningitis, encephalitis or meningoencephalitis. Its causative agent is the lymphocytic choriomeningitis virus (LCMV), a member of the family Arenaviridae. The name was coined by Charles Armstrong in 1934.
- Alternative Names
- LCMV GP1; Lymphocytic choriomeningitis virus Glycoprotein 1
- Gene ID
- 1491875
- UniProt ID
- P26804
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Brilliant Signal Clarity for T Cell Analysis
The BV421 fluorescent labeling ensures exceptional signal clarity, enabling precise identification of LCMV-specific T cells. This has significantly improved our ability to perform detailed immune profiling in viral research.
High Sensitivity and Specificity for Detection
As a staple in our lab's toolkit, this tetramer captures nuanced immune responses with high sensitivity, essential for comprehensive research into viral immunology.
Q&As
-
What is the primary application of the BV421-H-2Kb/LCMV gp34-43 MHC Tetramer?
A: This MHC tetramer is designed for the identification and analysis of antigen-specific CD8 T cells targeting the gp34-43 peptide of LCMV, presented by the H-2Kb MHC class I molecule. It is particularly used in flow cytometry to study immune responses in viral infections.
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Can this product be used to monitor immune responses in experimental models?
A: Yes, it is suitable for tracking T cell responses in mouse models of LCMV infection, helping evaluate the effectiveness of vaccines and treatments targeting viral infections.
View the frequently asked questions answered by Creative Biolabs Support.
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