Recombinant Anti-CD20 × Anti-CD28 Bispecific Antibody (Tandem Diabody)
CAT#: TAND-L027
Recombinant Anti-CD20 × Anti-CD28 Bispecific Antibody (Tandem Diabody) is a bispecific fusion protein with four binding sites, two of which bind to antigens of one kind of cells and the other two to the other kind of cells. Tandem Diabodies do not carry Fc domains. So they are smaller than whole IgGs or IgG-derived BsAbs but larger than tandem scFvs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with tandem scFvs. This BsAb is capable of inducing T-cell activation and effective tumor-cell killing without a signal through the TCR/CD3 complex. It was designed for the treatment of lymphoma.
Specifications
- Target
- CD20 & CD28
- Type
- Tandem Diabody
- Species Reactivity
- Human
- Target 1
- CD20
- Host Species 1
- Mouse
- Target 2
- CD28
- Host Species 2
- Human
- Application
- FuncS, Promising therapeutic agent
- Related Disease
- Lymphoma
Target
- Target 1
- CD20
- Gene ID
- 931
- UniProt ID
- A0A024R507
- Alternative Names
- MS4A1; membrane-spanning 4-domains, subfamily A, member 1; B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-16; B-lymphocyte antigen CD20; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16; B-lymphocyte cell-surface antigen B1
- Target 2
- CD28
- Gene ID
- 940
- UniProt ID
- B4E0L1
- Alternative Names
- CD28; CD28 molecule; Tp44; T-cell-specific surface glycoprotein CD28; CD28 antigen
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAB-L060 | Recombinant Anti-CD20 × Anti-CD28 Bispecific Antibody (Fab2) | FuncS, Promising therapeutic agent | Fab2 |
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