Recombinant Anti-CD22 × Anti-CD19 Bispecific Antibody (Tandem Diabody)
CAT#: TAND-L038
Recombinant Anti-CD22 × Anti-CD19 Bispecific Antibody (Tandem Diabody) is a bispecific fusion protein with four binding sites, two of which bind to one cell surface antigens and the other two to the other cells. Tandem Diabodies do not carry Fc domains. So they are smaller than whole IgGs or IgG-derived BsAbs but larger than tandem scFvs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with tandem scFvs. It was designed for the treatment of breast cancer, non-Hodgkin's lymphoma (NHL), acute myeloid leukemia (AML).
Specifications
- Target
- CD22 & CD19
- Type
- Tandem Diabody
- Species Reactivity
- Human
- Target 1
- CD22
- Host Species 1
- Human
- Target 2
- CD19
- Host Species 2
- Human
- Application
- FuncS, Promising therapeutic agent
- Related Disease
- Breast cancer, Non-Hodgkin's lymphoma (NHL), Acute myeloid leukemia (AML)
Target
- Target 1
- CD22
- Gene ID
- 933
- UniProt ID
- P20273
- Alternative Names
- CD22; CD22 molecule; SIGLEC2; SIGLEC-2; B-cell receptor CD22; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2
- Target 2
- CD19
- Gene ID
- 930
- UniProt ID
- P15391
- Alternative Names
- CD19; CD19 molecule; B4; CVID3; B-lymphocyte antigen CD19; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4
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