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CD22 & CD19

Anti-CD22 & CD19 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


CD22 is a B-cell-specific transmembrane glycoprotein belonging to the SIGLEC (sialic acid-binding immunoglobulin-like lectin) family. It is encoded by the CD22 gene located on chromosome 19q13.1. CD22 plays a crucial role in B-cell signaling and immune response modulation. It acts primarily as an inhibitory co-receptor that regulates B-cell receptor (BCR) signaling, thereby preventing overactivation of B cells and reducing the risk of autoimmunity. CD22 binds to sialylated glycans and recruits SHP-1 (Src homology region 2 domain-containing phosphatase-1), a phosphatase that dampens signaling cascades.
CD22 & CD19
CD19 (CD19 Molecule) is a Protein Coding gene. Diseases associated with CD19 include Immunodeficiency, Common Variable, 3 and Common Variable Immunodeficiency. Among its related pathways are RET signaling and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include signal transducer activity, downstream of receptor.
CD22 & CD19
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