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    CD22 & CD19

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    Anti-CD22 & CD19 Products

    • Anti-CD22 (RFB4)-mcc-DM1 ADC (ADC-028LCT)
      • Target: CD22
      • Linker: mcc (Maleimidomethyl cyclohexane-1-carboxylate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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    • Anti-CD22-MC-MMAF ADC (ADC-032LCT)
      • Target: CD22
      • Linker: Mc (maleimidocaproyl)
      • Drug: MMAF (Monomethyl auristatin F)
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    • Anti-CD22-MCC-DM1 ADC (ADC-033LCT)
      • Target: CD22
      • Linker: mcc (Maleimidomethyl cyclohexane-1-carboxylate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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    • Anti-CD19 (huB4)-SPDB-DM4 ADC (ADC-020LCT)
      • Target: CD19
      • Linker: SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
      • Drug: DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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    • Anti-CD22 (clone hu10F4)-MCC-DM1 ADC (ADC-027LZY)
      • Target: CD22
      • Linker: MCC (4-(N-maleimidomethyl)cyclohexane-1-carboxylate)
      • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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    • Anti-CD22-mc-vc-PABc-MMAE ADC (ADC-033LZY)
      • Target: CD22
      • Linker: mc-VC-PABc(maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
      • Drug: MMAE (monomethyl auristatin E)
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    • Anti-CD22-mc-vc-PABc-NMS249 ADC (ADC-097LZY)
      • Target: CD22
      • Linker: mc-VC-PABc (maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
      • Drug: NMS249
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    • Anti-CD19 (clone B496)-SPP-DM1 ADC (ADC-181LZY)
      • Target: CD19
      • Linker: SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate)
      • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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    • Anti-CD19 (clone B496)-MCC-DM1 ADC (ADC-182LZY)
      • Target: CD19
      • Linker: MCC (Maleimidomethyl cyclohexane-1-carboxylate)
      • Drug: DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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    • Anti-CD19 (clone huB4)-SMCC-DM1 ADC (ADC-157LZY)
      • Target: CD19
      • Linker: SMCC (4-[N-maleimidomethyl] cyclohexane-1 carboxylhydrazide).
      • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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    For Research Use Only. Not For Clinical Use.


    Background

    Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
    CD22 & CD19
    CD22 (CD22 Molecule) is a Protein Coding gene. Diseases associated with CD22 include refractory hematologic cancer and colon lymphoma. Among its related pathways are Immune System and Downstream signaling events of B Cell Receptor (BCR). GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is VCAM1.
    CD22 & CD19
    Related Diseases
    Primary Immunodeficiency Primary Immunodeficiency
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