Recombinant Anti-EGFR × Anti-ErbB-3 Bispecific Antibody (Fab2, PB4522)
CAT#: FAB-MZ007
This bispecific antibody comprising a first antigen-binding site that binds EGFR and a second antigen-binding site that binds ErbB-3 can inhibit the proliferation of pancreatic cancer cells. It is capable of induceing ADCC (Dependent cell-mediated cytotoxicity) activity towards the EGFR amplified cell line, which is an important anti-tumour mechanism of action for therapeutic antibodies in cancer.
Specifications
- Target
- EGFR & ErbB-3
- Type
- Fab2
- Species Reactivity
- Human
- Target 1
- EGFR
- Host Species 1
- Human
- Target 2
- ErbB-3
- Host Species 2
- Human
- Application
- FC, ADCC Reporter Bioassay
- Related Disease
- Pancreatic cancer
Target
- Target 1
- EGFR
- Gene ID
- 1956
- UniProt ID
- P00533
- Alternative Names
- EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
- Target 2
- ErbB-3
- Gene ID
- 2065
- UniProt ID
- P21860
- Alternative Names
- ERBB3; erb-b2 receptor tyrosine kinase 3; HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; receptor tyrosine-protein kinase erbB-3; proto-oncogene-like protein c-ErbB-3; human epidermal growth factor receptor 3; tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
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