Recombinant Anti-MUC1 × Anti-CD3 Bispecific Antibody (Fab₂) is composed of the Fab of the anti-MUC1 monoclonal antibody and Fab of an antibody specific for CD3. A linker is added between the two Fab. The bispecific antibody is somewhat smaller than a whole IgG and therefore it clears from the blood naturally at a faster rate. This BsAb is capable of targeting the tumor and recruiting T effector cells via binding to the CD3 subunit of the T cell receptor complex. It was designed for the treatment of breast cancer.

Specifications

Target

Target 1
MUC1

Gene ID
4582

UniProt ID
P15941

Alternative Names
MUC1; mucin 1, cell surface associated; EMA; MCD; PEM; PUM; KL-6; MAM6; MCKD; PEMT; CD227; H23AG; MCKD1; MUC-1; ADMCKD; ADMCKD1; CA 15-3; MUC-1/X; MUC1/ZD; MUC-1/SEC; mucin-1; episialin; DF3 antigen; H23 antigen; cancer antigen 15-3; krebs von den Lungen-

Target 2
CD3

Gene ID
916

UniProt ID
P07766

Alternative Names
CD3E; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3

Downloads

Customer Reviews and Q&As