EETI-II scaffold protein anti-Human Neutrophil elastase (CAT#: SEE-L085)
The EETI-II that bound Neutrophil elastase was isolated from the library using mRNA display techonology. After affinity maturation, EETI-II variants were identified having affinities (KD=160 pM) for Neutrophil elastase as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
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Normal Tissue
RNA Expression
Figure 1 Bone marrow
(Hematopoietic cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73774/170937_B_6_4.jpg
(Hematopoietic cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73774/170937_B_6_4.jpg
Figure 2 RNA cell line category: Cell line enriched (THP-1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000197561-ELANE
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000197561-ELANE
Figure 2 RNA cell line category: Cell line enriched (THP-1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000197561-ELANE
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000197561-ELANE
Specifications
- Scaffold Name
- EETI-II
- Origin
- Trypsin-specific squash inhibitor EETI II
- Core Structure
- Coiled, cys-rich (28)
- Variable Regions
- 6 aa
- Target
- Neutrophil elastase
- Species Reactivity
- Human
- Expression Host
- E. coli
- Affinity Constant
- 160 pM
- Applications
- ELISA; IHC; Microscopy; FC; WB; FuncS
Target
- Alternative Names
- trypsin-specific squash inhibitor EETI II; EETI-II; GE; NE; HLE; HNE; ELA2; SCN1; PMN-E
- Gene ID
- 1991
- UniProt ID
- P08246
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-1041 | Mouse Anti-ELANE Recombinant Antibody (clone YC039); Fab Fragment | ELISA | Mouse Fab |
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For Research Use Only. Not For Clinical Use.
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