Infliximab
CAT#: TP-088CL
Tumor necrosis factor (TNF-alpha) binding antibody (chimeric IgG1). It is composed of human constant and murine variable regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion
Gene Expression
Normal Tissue
Figure 1 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1245/3618_A_9_3.jpg
Normal Tissue
Figure 2 Liver
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1245/3618_A_9_4.jpg
Normal Tissue
Figure 3 Kidney
Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1245/3618_A_8_5.jpg
Normal Tissue
Figure 4 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1245/3618_A_5_6.jpg
RNA Expression
Figure 5 RNA cell line category: Group enriched (Karpas-707, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000211896-IGHG1
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Specifications
- Type
- Biotech
- Trade name
- Remicade
- UNII
- B72HH48FLU
Target
- Function
- Chimeric mAb that binds and neutralizes TNFa, preventing induction of pro-inflammatory cytokines, changes in endothelial permeability, activation of eosinophils and neutrophils, induction of acute phase reactants, and enzyme elaboration by synoviocytes and/or chondrocytes
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Customer Review
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Consistent Binding
I have employed the Infliximab antibody in several binding studies involving TNF-alpha. The chimeric IgG1 structure provided reliable affinity and stability during the experiments. The product description clearly outlined the recombinant production process, ensuring that I was confident in the reproducibility of my experimental setups.
Good Quality
My research on cytokine interactions benefited from the detailed specifications of this Infliximab antibody. The antibody's chimeric nature combining human constant and murine variable regions enabled consistent performance in binding assays. The provided details on production, purity and handling were invaluable to obtaining reliable results.
Q&As
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Can you explain the binding properties of Infliximab in research settings?
A: We have observed that Infliximab, a chimeric IgG1 antibody, exhibits robust binding to TNF-alpha. Its structure, combining human constant and murine variable regions, provides stable binding in vitro. This consistency in binding makes it suitable for research assays investigating TNF-alpha interactions and cytokine signaling pathways.
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What key details should be noted regarding its production and use?
A: We produce Infliximab using a recombinant cell line cultured by continuous perfusion, ensuring reliable quality and consistency. The product details, including its high purity and specific binding properties, assist researchers in optimizing assay conditions for in vitro studies focused on TNF-alpha interactions. Following the recommended titration guidelines yields optimal experimental results.
View the frequently asked questions answered by Creative Biolabs Support.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TP-088CL, RRID: AB_3112051)
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Biosimilar Overview
Please refer to Infliximab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Infliximab.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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