Kunitz domains scaffold protein anti-Human αvβ3 integrin (CAT#: SKD-L094)

The Kunitz domain that bound αvβ3 integrin was isolated from the library using phage display techonology. Kunitz domains are stable as standalone peptides, able to recognise specific protein structures, and also work as competitive protease inhibitors in their free form. After affinity maturation, Kunitz domains variants were identified having affinities (KD=0.3 nM) for αvβ3 integrin as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.


Specific Inquiry
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  • Datasheet
  • MSDS
  • COA

Specifications

  • Scaffold Name
  • Kunitz domains
  • Origin
  • Knottin protein
  • Variable Regions
  • 9-13 amino acids
  • Target
  • αvβ3 integrin
  • Species Reactivity
  • Human
  • Expression Host
  • E. coli
  • Affinity Constant
  • 0.3 nM
  • Applications
  • ELISA; IHC; Microscopy; FC; WB; FuncS

Target

  • Alternative Names
  • knottin protein; Kunitz domains; αvβ3 Integrin; αVβ3; integrin

Downloads

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Humanized Antibody

CAT Product Name Application Type
TAB-705 Anti-αvβ3 Integrin Recombinant Antibody (Etaracizumab/Etaratuzumab/Medi-522) FC, IP, ELISA, Neut, FuncS, IF, IHC IgG2 - kappa

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-705 Afuco™ Anti-αVβ3 Integrin ADCC Recombinant Antibody (Etaracizumab), ADCC Enhanced FC, IP, ELISA, Neut, FuncS, IF ADCC enhanced antibody

scFv Fragment Antibody

Fab Fragment Antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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