Kunitz domains anti-αvβ3 Integrin (SKD-L094)
The Kunitz domain that bound αvβ3 integrin was isolated from the library using phage display techonology. Kunitz domains are stable as standalone peptides, able to recognise specific protein structures, and also work as competitive protease inhibitors in their free form. After affinity maturation, Kunitz domains variants were identified having affinities (KD=0.3 nM) for αvβ3 integrin as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
Specifications
- Scaffold Name
- Kunitz domains
- Origin
- Knottin protein
- Variable Regions
- 9-13 amino acids
- Target
- αvβ3 integrin
- Species Reactivity
- Human
- Expression Host
- E. coli
- Affinity Constant
- 0.3 nM
- Applications
- ELISA; IHC; Microscopy; FC; WB; FuncS
Target
- Alternative Names
- knottin protein; Kunitz domains; αvβ3 Integrin; αVβ3; integrin
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
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