Kunitz domains scaffold protein anti-Human Factor Xia (CAT#: SKD-L098)
The Kunitz domain that bound Factor Xia was isolated from the library using phage display techonology. Kunitz domains are stable as standalone peptides, able to recognise specific protein structures, and also work as competitive protease inhibitors in their free form. After affinity maturation, Kunitz domains variants were identified having affinities for Factor Xia as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
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Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line Hep G2
(Immunofluorescent staining of human cell line Hep G2 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/39808/1663_A5_1_selected.jpg
(Immunofluorescent staining of human cell line Hep G2 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/39808/1663_A5_1_selected.jpg
Figure 2 RNA cell line category: Cell line enriched (Hep G2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000088926-F11
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000088926-F11
Specifications
- Scaffold Name
- Kunitz domains
- Origin
- APPI
- Core Structure
- α-helices, β-sheets
- Variable Regions
- 1–2 Loops
- Target
- Factor Xia
- Species Reactivity
- Human
- Expression Host
- E. coli
- Applications
- ELISA; IHC; Microscopy; FC; WB; FuncS
Target
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-342 | Recombinant Anti-human F11 Antibody | ELISA, WB, IF, FuncS | IgG |
| HPAB-N0313-YC | Human Anti-F11 Recombinant Antibody (HPAB-N0313-YC) | ELISA | Human IgG |
| HPAB-M0357-YC | Human Anti-F11 Recombinant Antibody (HPAB-M0357-YC) | Inhib, FuncS | Human IgG4 (S228P) Q1E M103L, κ |
| HPAB-M0358-YC | Human Anti-F11 Recombinant Antibody (HPAB-M0358-YC) | Inhib, FuncS | Human IgG4 (S228P), κ |
| HPAB-N0087-YC | Human Anti-F11 Recombinant Antibody (HPAB-N0087-YC) | ELISA, Inhib | Humanized IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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