Kunitz domains scaffold protein anti-Human TNFR1 (CAT#: SKD-L114)
The Kunitz domain that bound TNFR1 was isolated from the library using Phage display techonology. Kunitz domains are stable as standalone peptides, able to recognise specific protein structures, and also work as competitive protease inhibitors in their free form. After affinity maturation, Kunitz domains variants were identified having affinities for TNFR1 as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Cerebral cortex
(Glial cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10309/25571_B_7_5.jpg
(Glial cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10309/25571_B_7_5.jpg
Figure 2 Colon
(Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10309/25571_A_7_3.jpg
(Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10309/25571_A_7_3.jpg
Figure 3 Kidney
(Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10309/25571_A_9_5.jpg
(Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10309/25571_A_9_5.jpg
Figure 4 Testis
(Cells in seminiferous ducts
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10309/25571_A_6_6.jpg
(Cells in seminiferous ducts
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10309/25571_A_6_6.jpg
Figure 5 Lymph node
(Germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10309/25571_A_9_8.jpg
(Germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10309/25571_A_9_8.jpg
Figure 6 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000067182-TNFRSF1A
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000067182-TNFRSF1A
Specifications
- Scaffold Name
- Kunitz domains
- Origin
- Insect defensinA (1ICA29)
- Core Structure
- α-helices, β-sheets
- Variable Regions
- 2 loops
- Target
- TNFR1
- Species Reactivity
- Human
- Expression Host
- BL21 (DE3) cells
- Applications
- ELISA; IHC; Microscopy; FC; WB; FuncS
Target
- Alternative Names
- Insect defensinA (1ICA29); Kunitz domains; FPF; MS5; p55; p60; TBP1; TNF-R; TNFAR; TNFR1; p55-R; CD120a; TNFR55; TNFR60; TNF-R-I; TNF-R55; TNFR1-d2
- Gene ID
- 7132
- UniProt ID
- P19438
Downloads
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See other products for "TNFRSF1A"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1440z | Mouse Anti-TNFRSF1A Recombinant Antibody (clone 37C9) | FC, IHC, IP, Neut, FuncS | Mouse IgG2a |
| MOB-1589MZ | Recombinant Mouse Anti-Human TNFRSF1A Antibody (clone NN0683-6E42) | Neut, WB | Mouse antibody |
| HPAB-1695LY | Human Anti-TNFRSF1A Recombinant Antibody (HPAB-1695LY) | ELISA, FC, Inhib, FuncS | Humanized IgG |
| HPAB-1696LY | Human Anti-TNFRSF1A Recombinant Antibody (HPAB-1696LY) | ELISA, FC, Inhib, FuncS | Humanized IgG |
| MOB-111LC | Mouse Anti-TNFRSF1A Recombinant Antibody (clone 16803R), Alexa Fluor 488 | FC | Mouse IgG1 |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-106CQ | Mouse Anti-TNFRSF1A Recombinant Antibody (TAB-106CQ) | WB, FC, IHC | Mouse IgG2a, κ |
| TAB-106CQ-S(P) | Mouse Anti-TNFRSF1A Recombinant Antibody; scFv Fragment (TAB-106CQ-S(P)) | ELISA, FC, Neut | Mouse scFv |
| TAB-106CQ-F(E) | Mouse Anti-TNFRSF1A Recombinant Antibody; Fab Fragment (TAB-106CQ-F(E)) | ELISA, FC, Neut | Mouse Fab |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-107CQ | Human Anti-TNFRSF1A Recombinant Antibody (TAB-107CQ) | ELISA, FC, Neut | Humanized antibody |
| TAB-107CQ-S(P) | Human Anti-TNFRSF1A Recombinant Antibody; scFv Fragment (TAB-107CQ-S(P)) | ELISA, FC, Neut | Humanized scFv |
| TAB-107CQ-F(E) | Human Anti-TNFRSF1A Recombinant Antibody; Fab Fragment (TAB-107CQ-F(E)) | ELISA, FC, Neut | Humanized Fab |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2142CQ | Hamster Anti-Tnfrsf1a Recombinant Antibody (clone 55R-593) | Neut, IP | Hamster IgG |
| NEUT-2143CQ | Hamster Anti-Tnfrsf1a Recombinant Antibody (clone 55R-170) | FuncS, Neut | Hamster IgG |
| NEUT-2144CQ | Hamster Anti-Tnfrsf1a Recombinant Antibody (clone CBL802) | WB, IP, Neut | Hamster IgG |
| NEUT-2145CQ | Hamster Anti-Tnfrsf1a Recombinant Antibody (clone CBL178) | FC, ELISA, WB, IP, Neut | Hamster IgG |
| NEUT-2146CQ | Mouse Anti-TNFRSF1A Recombinant Antibody (clone 5D31) | Neut, WB | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3613 | Rabbit Anti-TNFRSF1A Recombinant Antibody (clone DS3613AB) | WB, FC | Rabbit IgG |
| MOR-3614 | Rabbit Anti-Tnfrsf1a Recombinant Antibody (clone DS3614AB) | ELISA | Rabbit IgG |
Agonistic Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-097LC | Rat Anti-Tnfrsf1a Recombinant Antibody (clone HM102) | IP, IHC, FC | Rat IgG2a |
Neuroscience Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-102CN | Camelid Anti-TNFRSF1A Recombinant Single Domain Antibody (clone DOM1h-574-188) | ELISA | Camelid VHH |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1695LY-S(P) | Human Anti-TNFRSF1A Recombinant Antibody; scFv Fragment (HPAB-1695LY-S(P)) | ELISA, FC, Inhib | Human scFv |
| HPAB-1696LY-S(P) | Human Anti-TNFRSF1A Recombinant Antibody; scFv Fragment (HPAB-1696LY-S(P)) | ELISA, FC, Inhib | Human scFv |
| HPAB-N0275-YC-S(P) | Human Anti-TNFRSF1A Recombinant Antibody; scFv Fragment (HPAB-N0275-YC-S(P)) | ELISA | Human scFv |
| HPAB-1441-FY-S(P) | Human Anti-TNFRSF1A Recombinant Antibody; scFv Fragment (HPAB-1441-FY-S(P)) | ELISA, Inhib, IF, FC | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1695LY-F(E) | Human Anti-TNFRSF1A Recombinant Antibody; Fab Fragment (HPAB-1695LY-F(E)) | ELISA, FC, Inhib | Humanized Fab |
| HPAB-1696LY-F(E) | Human Anti-TNFRSF1A Recombinant Antibody; Fab Fragment (HPAB-1696LY-F(E)) | ELISA, FC, Inhib | Humanized Fab |
| HPAB-N0275-YC-F(E) | Human Anti-TNFRSF1A Recombinant Antibody; Fab Fragment (HPAB-N0275-YC-F(E)) | ELISA | Human Fab |
| HPAB-1441-FY-F(E) | Human Anti-TNFRSF1A Recombinant Antibody; Fab Fragment (HPAB-1441-FY-F(E)) | ELISA, Inhib, IF, FC | Human Fab |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-J0305-YC | Recombinant Human Anti-TNFRSF1A Single Domain Antibody (DOMlh-549) | ELISA, Inhib | Human VHH |
| HPAB-J0306-YC | Recombinant Human Anti-TNFRSF1A Single Domain Antibody (DOMlh-574) | ELISA, Inhib | Human VHH |
| HPAB-J0307-YC | Recombinant Human Anti-TNFRSF1A Single Domain Antibody (DOMlh-574-16) | ELISA, Inhib | Human VHH |
| HPAB-J0308-YC | Recombinant Human Anti-TNFRSF1A Single Domain Antibody (DOMlh-574-109) | ELISA, Inhib | Human VHH |
| HPAB-J0309-YC | Recombinant Human Anti-TNFRSF1A Single Domain Antibody (DOMlh-131-206) | ELISA, Inhib | Human VHH |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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