PE-A*02:01/CMV pp65 (NLVPMVATV) MHC Tetramer
CAT#: MHC-LC348
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of CMV-derived peptide of NLVPMVATV sequence covering 495-503 and A*02:01 molecule. The pMHC tetramer recognizes human CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Specifications
- Allele
- A*02:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- CMV pp65
- Antigen Species
- CMV
- Peptide
- NLVPMVATV
- Range
- 495-503
- Conjugate
- PE
- Application
- FCM
Target
- Antigen Introduction
- Human cytomegalovirus is a species of the Cytomegalovirus genus of viruses, which in turn is a member of the viral family known as Herpesviridae or herpesviruses. It is typically abbreviated as HCMV or, commonly but more ambiguously, as CMV. It is also known as human herpesvirus-5 (HHV-5). pp65 (ppUL83), the major constituent of both virions and noninfectious particles called dense bodies, localizes predominantly to the nucleus after virus penetration and accumulates in both nucleus and cytoplasm as virus matures late in infection, where it may associate with a kinase.
- Alternative Names
- CMV pp65; Human cytomegalovirus pp65; UL83; lower matrix protein
- Gene ID
- 911829
- UniProt ID
- Q05320
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Effective in T-Cell Analysis
I found the CMV pp65 MHC Tetramer particularly effective for analyzing T-cell responses. Its ability to pinpoint CMV-specific CD8 T cells was invaluable in my immunology project. The bright PE conjugate made sorting and identifying cells straightforward. I highly recommend it for anyone working on antigen-specific T-cell studies.
Valuable for Immune Response Studies
Understanding CMV-specific immune responses became far easier with this tetramer. It's particularly useful in studies involving immune suppression and transplant patients, as it helps us gauge the latency virus's activity through T-cell profiling.
Dependable and Cost-Effective
Dependability paired with cost-effectiveness make this tetramer a staple in our research procedures. Balancing performance with budget is crucial, and this product delivers excellent value for serious research endeavors.
Q&As
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What is the main function of the CMV pp65 MHC Tetramer?
A: This tetramer is primarily used to identify and study human CD8 T cells that are specific to the CMV pp65 antigen. It plays a crucial role in immunological research, particularly in assessing the specificity and diversity of T-cell responses against the cytomegalovirus, an important aspect of virology studies.
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What are the specific applications of this MHC tetramer in research?
A: The tetramer is used extensively in flow cytometry to analyze T-cell populations. It helps researchers in immunology to quantify and characterize antigen-specific CD8 T cells, providing insights into immune responses and aiding in the development of vaccines.
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Can this tetramer be used in clinical diagnostics?
A: No, this product is for research use only. It is not intended for clinical diagnostic or therapeutic use, as specified by Creative Biolabs, emphasizing its role exclusively in laboratory-based research.
View the frequently asked questions answered by Creative Biolabs Support.
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| PABC-118 | Recombinant Human Anti-CMV pp65 Antibody (MO61) | BL | IgG |
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| PFBC-118 | Recombinant Human Anti-CMV pp65 Antibody Fab Fragment (MO61) | BL |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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