PE-A*02:01/Human PRAME (SLLQHLIGL) MHC Tetramer (CAT#: MHC-LC185)
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of PRAME-derived peptide of SLLQHLIGL sequence covering 425-433 and A*02:01 molecule. The pMHC tetramer recognizes human CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Specific Inquiry
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line K-562
(Immunofluorescent staining of human cell line K-562 shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/68562/1854_A5_4_selected.jpg
(Immunofluorescent staining of human cell line K-562 shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/68562/1854_A5_4_selected.jpg
Figure 2 Colon
(Glandular cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/45153/160303_A_7_3.jpg
(Glandular cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/45153/160303_A_7_3.jpg
Figure 3 Testis
(Elongated or late spermatids
Staining: High
Intensity: Strong
Quantity:>75%
Leydig cells
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Pachytene spermatocytes
Staining: High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/45153/160303_A_5_6.jpg
(Elongated or late spermatids
Staining: High
Intensity: Strong
Quantity:>75%
Leydig cells
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Pachytene spermatocytes
Staining: High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/45153/160303_A_5_6.jpg
Figure 4 RNA cell line category: Cell line enriched (K-562)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000185686-PRAME/subcellular
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000185686-PRAME/subcellular
Specifications
- Allele
- A*02:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- PRAME
- Antigen Species
- Human
- Peptide
- SLLQHLIGL
- Range
- 425-433
- Conjugate
- PE
- Application
- FCM
Target
- Antigen Introduction
- This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants.
- Alternative Names
- PRAME; preferentially expressed antigen in melanoma; MAPE; OIP4; CT130; OIP-4
- Gene ID
- 23532
- UniProt ID
- Q05320
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Customer Reviews and Q&As
Customer Review
Q&As
Excellent for T Cell Analysis
Using this tetramer, our group has made significant progress in identifying T cell populations specific to tumor antigens. The high specificity and reliability allow us to confidently evaluate the immune response in various cancer tissue samples.
Integrates Seamlessly with Flow Cytometry
This tetramer integrates seamlessly into our flow cytometry analysis. The PE conjugate offers bright signals that are easy to detect and quantify, making our data analysis straightforward and reliable.
Key to Personalized Immunotherapy Research
The detailed T cell profiling it allows has been key to tailoring immunotherapy research to individuals' tumors in our precision medicine projects. It's a must-have for anyone engaged in personalized cancer treatment research.
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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