PE-A*03:01/Human ABL1 (GKQSSKALQR) MHC Tetramer (CAT#: MHC-LC2237)

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human ABL1 of peptide GKQSSKALQR and A*03:01 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.


Specific Inquiry
  • Size:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression

Specifications

  • Allele
  • A*03:01
  • Class
  • Class I
  • Antigen
  • ABL1
  • Antigen Species
  • Human
  • Peptide
  • GKQSSKALQR
  • Conjugate
  • PE
  • Application
  • FCM

Target

  • Antigen Introduction
  • This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.
  • Alternative Names
  • ABL1; ABL proto-oncogene 1, non-receptor tyrosine kinase; ABL; JTK7; p150; c-ABL; v-abl; c-ABL1; bcr/abl

Related Resources

  • Related Signaling Pathways

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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