APC-A1/Human FBL (VSDIVGPDGLVY) MHC Tetramer (CAT#: MHC-LC3406)
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human FBL of peptide VSDIVGPDGLVY covering 177-188 and A1 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & nucleoli fibrillar center.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49546/756_G8_1_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & nucleoli fibrillar center.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49546/756_G8_1_selected.jpg
Figure 2 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoli fibrillar center.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1514/652_H1_1_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoli fibrillar center.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1514/652_H1_1_selected.jpg
Figure 3 IHC staining of human pancreas
(Immunohistochemical staining of human pancreas shows nuclear positivity in exocrine glandular cells and cells in islets of Langerhans.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/77724/168552_A_2_3_selected.jpg
(Immunohistochemical staining of human pancreas shows nuclear positivity in exocrine glandular cells and cells in islets of Langerhans.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/77724/168552_A_2_3_selected.jpg
Figure 4 IHC staining of human cerebellum
(Immunohistochemical staining of human cerebellum shows strong nuclear positivity in purkinje cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1514/ihc_selected.jpg
(Immunohistochemical staining of human cerebellum shows strong nuclear positivity in purkinje cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1514/ihc_selected.jpg
Figure 5 Cerebral cortex
(Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: nuclear Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1514/4603_B_9_5.jpg
(Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: nuclear Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1514/4603_B_9_5.jpg
Figure 6 Colon
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1514/4603_A_8_3.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1514/4603_A_8_3.jpg
Figure 7 Testis
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Spermatogonia cells Staining: Medium Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1514/4603_A_6_6.jpg
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Spermatogonia cells Staining: Medium Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1514/4603_A_6_6.jpg
Figure 8 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000105202-FBL
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000105202-FBL
Specifications
- Allele
- A1
- Class
- Class I
- MHC Species
- Human
- Antigen
- FBL
- Antigen Species
- Human
- Peptide
- VSDIVGPDGLVY
- Range
- 177-188
- Conjugate
- APC
- Application
- FCM
Target
- Antigen Introduction
- This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. [provided by RefSeq, Jul 2008]
- Alternative Names
- FBL; rRNA 2'-O-methyltransferase fibrillarin; FIB; FLRN; Nop1; RNU3IP1
- Gene ID
- 2091
- UniProt ID
- P22087
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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