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    PE-DRB1*04:01/Human ACAN (ATEYRVRVNSAYQDK) MHC Tetramer (CAT#: MHC-LC1814)

    This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of ACAN-derived peptide of ATEYRVRVNSAYQDK covering 89-103 and DRB1*04:01 molecule. The pMHC tetramer recognizes CD4 T cells, and can be used in the analysis of individual antigen-specific T cells.

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    Custom Production

    MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.

    Peptide Sequence *:
    Allele Requested *:
    Antigen Species:
    Antigen Molecule:
    Sequence Position:
    Form Requested *:
    Conjugation *:
    Size *:
    Comments:

    Disclaimer: Please note that the MHC reagents we offered have been produced with strict quality control (including gene sequencing, affinity purification, SDS-PAGE analysis, and verification of biotinylation), but many have not been confirmed to stain or activate specific T cells.

    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Normal Tissue
    Figure 1 Colon
    Figure 1 Colon
    (Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/38242/146198_A_7_3.jpg
    Figure 2 Kidney
    Figure 2 Kidney
    (Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/38242/146198_A_7_5.jpg
    Figure 3 Cerebral cortex
    Figure 3 Cerebral cortex
    (Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glial cells)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/38242/146198_B_9_5.jpg
    RNA Expression
    Figure 4 RNA cell line category: Cell line enriched (WM-115)
    Figure 4 RNA cell line category: Cell line enriched (WM-115)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000157766-ACAN

    Specifications

    • Allele
    • DRB1*04:01
    • Class
    • Class II
    • MHC Species
    • Human
    • Antigen
    • ACAN
    • Antigen Species
    • Human
    • Peptide
    • ATEYRVRVNSAYQDK
    • Range
    • 89-103
    • Conjugate
    • PE
    • Application
    • FCM

    Target

    • Antigen Introduction
    • This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene.
    • Alternative Names
    • ACAN; aggrecan; AGC1; SEDK; AGCAN; CSPG1; MSK16; CSPGCP

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    MOB-3746z Mouse Anti-ACAN Recombinant Antibody (clone 27H3) WB, IP, IF, IHC Mouse IgG1, κ
    MOB-0499MZ Mouse Anti-ACAN Recombinant Antibody (clone 7-C-5) ELISA, IF, IHC-Fr, IHC-P, WB Mouse IgG1
    MRO-0036-CN Rabbit Anti-ACAN Recombinant Antibody (clone JA40-23) IHC Rabbit IgG

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    For Research Use Only. Not For Clinical Use.

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