PE-H-2Db/HPV16 E7 (RAHYNIVTF) MHC Tetramer (CAT#: MHC-LC291)
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of HPV16-derived peptide of RAHYNIVTF sequence covering 49-57 and H-2Db molecule. The pMHC tetramer recognizes mouse CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Specific Inquiry
Specifications
- Allele
- H-2Db
- Class
- Class I
- MHC Species
- Mouse
- Antigen
- HPV16 E7
- Antigen Species
- HPV16
- Peptide
- RAHYNIVTF
- Range
- 49-57
- Conjugate
- PE
- Application
- FCM
Target
- Antigen Introduction
- Papillomaviridae is an ancient taxonomic family of non-enveloped DNA viruses, collectively known as papillomaviruses. Several hundred species of papillomaviruses, traditionally referred to as "types", have been identified infecting all carefully inspected mammals, but also other amniotes such as birds, snakes and turtles. Infection by most papillomavirus types, depending on the type, is either asymptomatic (e.g. most Beta-PVs) or causes small benign tumors, known as papillomas or warts (e.g. human papillomavirus1, HPV6 or HPV11). Papillomas caused by some types, however, such as human papillomaviruses 16 and 18, carry a risk of becoming cancerous.
- Alternative Names
- HPV16 E7; Human papillomavirus type 16 E7
- Gene ID
- 1489079
- UniProt ID
- P03129
Related Resources
Pellom, Samuel T., et al. "Characterization of recombinant gorilla adenovirus HPV therapeutic vaccine PRGN-2009." JCI insight 6.7 (2021). https://doi.org/10.1172/jci.insight.141912
The study investigates the efficacy of the recombinant gorilla adenovirus HPV therapeutic vaccine, PRGN-2009, targeting HPV-associated malignancies. PRGN-2009 is designed to express multiple cytotoxic T cell epitopes from the HPV 16/18 E6 and E7 proteins, aiming to stimulate strong HPV-specific immune responses. The vaccine was tested in both humanized and syngeneic mouse models bearing HPV16+ tumors. Results showed significant tumor volume reduction and increased infiltration of multifunctional CD8+ and CD4+ T cells in the tumor microenvironment. These findings suggest PRGN-2009's potential as an effective therapeutic vaccine for HPV-associated cancers.
Creative Biolabs provided crucial reagents for this study, including the mouse HPV16 E7 tetramer (CAT#: MHC-LC291). This tetramer was essential for evaluating antigen-specific CD8+ T cell responses in the tumor microenvironment. By facilitating the detailed assessment of immune cell infiltration and functionality, Creative Biolabs' products enabled a comprehensive analysis of PRGN-2009's immunogenicity and antitumor efficacy.
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IgM Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B047(A) | Recombinant Anti-HPV16 E7 Intrabody [(D-Arg)9] | ICC, Neut, FuncS | scFv-(D-Arg)9 |
| IAB-B047(G) | Recombinant Anti-HPV16 E7 Intrabody [+36 GFP] | ELISA, WB, ICC, FuncS | scFv-(+36GFP) |
| IAB-B047(T) | Recombinant Anti-HPV16 E7 Intrabody [Tat] | IF, FC, WB, FuncS | scFv-Tat |
Customer Reviews and Q&As
Customer Review
Q&As
Emily Walker
Ideal for MHC Tetramer Studies
Ideal for MHC Tetramer Studies
The PE-H-2Db-HPV16-E7 (49-57) MHC Tetramer has been excellent for our MHC tetramer research. Its specificity and sensitivity are top-notch, providing clear and reliable results. This antibody has significantly improved the accuracy of our experiments and saved us a lot of troubleshooting time.
16-Jul-23
John Martinez
Effective in Immunoassays
Effective in Immunoassays
We incorporated this antibody into our immunoassays, and it has been a great asset. The specificity for MHC tetramer is precise, allowing for accurate detection and analysis. The reliable performance has made it an invaluable tool in our lab.
12-Dec-22
Sarah Thompson
Consistent and Reliable
Consistent and Reliable
This antibody has proven to be consistent and reliable in our assays. The high-quality, reproducible results have significantly improved our experiments, making it a crucial part of our research toolkit. The strong affinity and specificity for MHC tetramer have been particularly beneficial.
08-Sep-21
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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