PE-H-2Db/HPV16 E7 (RAHYNIVTF) MHC Tetramer

Customer Review

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Emily Walker
16.Jul,23

Ideal for MHC Tetramer Studies

The PE-H-2Db-HPV16-E7 (49-57) MHC Tetramer has been excellent for our MHC tetramer research. Its specificity and sensitivity are top-notch, providing clear and reliable results. This antibody has significantly improved the accuracy of our experiments and saved us a lot of troubleshooting time.

John Martinez
12.Dec,22

Effective in Immunoassays

We incorporated this antibody into our immunoassays, and it has been a great asset. The specificity for MHC tetramer is precise, allowing for accurate detection and analysis. The reliable performance has made it an invaluable tool in our lab.

Sarah Thompson
08.Sep,21

Consistent and Reliable

This antibody has proven to be consistent and reliable in our assays. The high-quality, reproducible results have significantly improved our experiments, making it a crucial part of our research toolkit. The strong affinity and specificity for MHC tetramer have been particularly beneficial.

Q&As

1. Is the PE-H-2Db HPV16 E7 49-57 MHC Tetramer suitable for use in flow cytometry?

   A: Yes, the PE-H-2Db HPV16 E7 49-57 MHC Tetramer (MHC-LC291) is suitable for use in flow cytometry. It allows for the detection and analysis of antigen-specific T cells.

2. What are the storage recommendations for the PE-H-2Db HPV16 E7 49-57 MHC Tetramer?

   A: The recommended storage condition for the PE-H-2Db HPV16 E7 49-57 MHC Tetramer (MHC-LC291) is at 2-8°C. It should be protected from light and should not be frozen.

3. Can the PE-H-2Db HPV16 E7 49-57 MHC Tetramer be used in live-cell staining?

   A: Yes, the PE-H-2Db HPV16 E7 49-57 MHC Tetramer (MHC-LC291) can be used in live-cell staining. It allows for the identification of live antigen-specific T cells.

4. How do you titrate the PE-H-2Db HPV16 E7 49-57 MHC Tetramer for optimal use?

   A: It is recommended to titrate the PE-H-2Db HPV16 E7 49-57 MHC Tetramer (MHC-LC291) starting at 1:50 and adjust based on the specific experimental conditions.

5. What is the application of PE-H-2Db HPV16 E7 49-57 MHC Tetramer in immunological research?

   A: The PE-H-2Db HPV16 E7 49-57 MHC Tetramer (MHC-LC291) is used to detect and quantify antigen-specific CD8+ T cells in immunological research, particularly in studies related to HPV infection and immune response.

View the frequently asked questions answered by Creative Biolabs Support.

Citations

1. Pellom, Samuel T., et al. "Characterization of recombinant gorilla adenovirus HPV therapeutic vaccine PRGN-2009." JCI insight 6.7 (2021). https://doi.org/10.1172/jci.insight.141912
   The study investigates the efficacy of the recombinant gorilla adenovirus HPV therapeutic vaccine, PRGN-2009, targeting HPV-associated malignancies. PRGN-2009 is designed to express multiple cytotoxic T cell epitopes from the HPV 16/18 E6 and E7 proteins, aiming to stimulate strong HPV-specific immune responses. The vaccine was tested in both humanized and syngeneic mouse models bearing HPV16+ tumors. Results showed significant tumor volume reduction and increased infiltration of multifunctional CD8+ and CD4+ T cells in the tumor microenvironment. These findings suggest PRGN-2009's potential as an effective therapeutic vaccine for HPV-associated cancers.
   Creative Biolabs provided crucial reagents for this study, including the mouse HPV16 E7 tetramer (CAT#: MHC-LC291). This tetramer was essential for evaluating antigen-specific CD8+ T cell responses in the tumor microenvironment. By facilitating the detailed assessment of immune cell infiltration and functionality, Creative Biolabs' products enabled a comprehensive analysis of PRGN-2009's immunogenicity and antitumor efficacy.

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