PE-H-2Kb/OVA (SIIGFEKL) MHC Tetramer
CAT#: MHC-LC653
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of OVA-derived peptide of SIIGFEKL sequence covering 257-264 and H-2Kb molecule. The pMHC tetramer recognizes mouse CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Specifications
- Allele
- H-2Kb
- Class
- Class I
- MHC Species
- Mouse
- Antigen
- OVA
- Antigen Species
- Gallus gallus
- Peptide
- SIIGFEKL
- Range
- 257-264
- Conjugate
- PE
- Application
- FCM
Target
- Antigen Introduction
- Ovalbumin (abbreviated OVA) is the main protein found in egg white, making up approximately 55% of the total protein. Ovalbumin displays sequence and three-dimensional homology to the serpin superfamily, but unlike most serpins it is not a serine protease inhibitor. The function of ovalbumin is unknown, although it is presumed to be a storage protein.
- Alternative Names
- OVA; Ovalbumin
- Gene ID
- 396058
- UniProt ID
- P01012
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Great for Immunology Studies
I have been using the PE-H-2Kb/OVA MHC Tetramer for some time, and it's been invaluable in my immune response studies. Its specificity and high fluorescence allow detailed analysis of CD8+ T cell populations, which is crucial for my research on immune therapies.
Highly Effective for T Cell Analysis
We employed this tetramer in our lab's studies on T cell responses to cancer. It worked seamlessly with our flow cytometry setup, providing clear, distinct results. The PE fluorescence was notably strong, making it easier to differentiate specific T cell populations.
Enhanced Flow Cytometry Experience
Transitioning to using this tetramer improved our flow cytometry results substantially. The added sensitivity and specificity for CD8+ T cell recognition have been apparent in the clarity of our data outputs, even in complex samples.
Q&As
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What is the primary application of the PE-H-2Kb/OVA MHC Tetramer?
A: The PE-H-2Kb/OVA MHC Tetramer is primarily used in flow cytometry to analyze antigen-specific CD8+ T cells in mouse models. Researchers utilize this tool to measure immune responses, particularly in studies involving ovalbumin as a model antigen.
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What are the typical research areas where this tetramer is used?
A: The PE-H-2Kb/OVA MHC Tetramer is often used in immunology studies, including cancer research, vaccine development, and autoimmune disease exploration, among others. Its applications are broad, given its role in tracking T cell responses.
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What controls should I consider using with this tetramer in assays?
A: Appropriate controls include staining with a non-specific tetramer or using cells known to lack the T cell receptor specificity for SIIGFEKL. Isotype controls and unstained cells are also recommended for accurate analysis.
View the frequently asked questions answered by Creative Biolabs Support.
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Datasheet
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See other products for "OVA"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC648 | BV421-H-2Kb/OVA (SIINFEKL) MHC Tetramer | FCM | |
| MHC-LC649 | PE-H-2Kb/OVA (SIINFEKL) MHC Tetramer | FCM | |
| MHC-LC650 | APC-H-2Kb/OVA (SIINFEKL) MHC Tetramer | FCM | |
| MHC-LC651 | PE-H-2Kb/OVA (EIINFEKL) MHC Tetramer | FCM | |
| MHC-YC233 | H-2Kb/Ovalbumin (KVVRFDKL) MHC Pentamer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-0167CQ | Mouse Anti-OVA Recombinant Antibody (clone Nos. 4) | WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0047 | APC-H-2Kb/Human OVA Mut (EIINFEKL) MHC Tetramer | FCM | |
| MHC-CN0048 | PE-H-2Kb/Human OVA Mut (EIINFEKL) MHC Tetramer | FCM | |
| MHC-CN0265 | APC-H-2Kb/Human OVA (SIINFEKL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1221WJ | Recombinant Dromedary Anti-OVA Single Domain Antibody (HPAB-1221WJ) | ELISA | Dromedary VHH |
| HPAB-1222WJ | Recombinant Dromedary Anti-OVA Single Domain Antibody (HPAB-1222WJ) | ELISA | Dromedary VHH |
| HPAB-1223WJ | Recombinant Dromedary Anti-OVA Single Domain Antibody (HPAB-1223WJ) | ELISA | Dromedary VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-0332C | Mouse Anti-OVA Recombinant Antibody (ZG-0332C) | WB, ELISA | Mouse IgG |
| ZG-487C | Mouse Anti-OVA Recombinant Antibody (clone 5A7A7) | ELISA | Mouse IgG1, κ |
| VS7-0425-WR529 | Mouse Anti-OVA Monoclonal Antibody (clone 3G2E1D9) | WB | Mouse IgG1 |
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