PE-HLA-A2/Human MLANA (AAGIGILTV) MHC Tetramer (CAT#: MHC-LC1367)
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of MLANA-derived peptide of AAGIGILTV covering 27-35 and HLA-A2 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 High expression in skin 1
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48662/167996_B_8_1_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48662/167996_B_8_1_val_selected.jpg
Figure 2 Low expression in liver
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48662/167996_A_8_4_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48662/167996_A_8_4_val_selected.jpg
Figure 3 Testis
(Leydig cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48662/167996_A_5_6.jpg
(Leydig cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48662/167996_A_5_6.jpg
Figure 4 RNA cell line category: Cell line enriched (SK-MEL-30)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120215-MLANA
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120215-MLANA
Specifications
- Allele
- HLA-A2
- Class
- Class I
- MHC Species
- Human
- Antigen
- Mart-1
- Antigen Species
- Human
- Peptide
- AAGIGILTV
- Range
- 27-35
- Conjugate
- PE
- Application
- FCM
Target
- Antigen Introduction
- Protein melan-A also known as melanoma antigen recognized by T cells 1 or MART-1 is a protein that in humans is encoded by the MLANA o "MALENA" gene. A fragment of the protein, usually consisting of the nine amino acids 27 to 35, is bound by MHC class I complexes which present it to T cells of the immune system. These complexes can be found on the surface of melanoma cells. Decameric peptides (26-35) are being investigated as cancer vaccines.
- Alternative Names
- MLANA; melan-A; MART1; MART-1
- Gene ID
- 2315
- UniProt ID
- Q16655
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1380z | Mouse Anti-MLANA Recombinant Antibody (clone 22A7) | ELISA, FC, ICC, IF, IHC, WB | Mouse IgG1 |
| MOB-0324MZ | Recombinant Mouse Anti-Human MLANA Antibody (clone B104) | IHC | Mouse antibody |
| MOB-0096F | Mouse Anti-MLANA Recombinant Antibody (MOB-0096F) | IHC-P, IF | Mouse IgG |
| ZG-0354U | Rabbit Anti-MLANA Recombinant Antibody (clone A19-P) | IHC-P | Rabbit IgG |
| VS3-WK1016 | Rabbit Anti-MLANA Recombinant Antibody (VS3-WK1016) | WB, IHC, FC | Rabbit IgG |
Customer Reviews and Q&As
Customer Review
Q&As
Accurate T-Cell Identification
The PE-HLA-A2/Human MLANA MHC Tetramer seamlessly identified MLANA-specific T cells in our melanoma study. The precision in T cell recognition enabled us to delve deeper into immune responses, offering us a detailed understanding of the specific responses against melanoma-associated antigens.
Perfect for Flow Cytometry
The PE conjugate offers high signal intensity, making it ideal for the flow cytometry applications. In our lab, this tetramer has become essential for effectively detecting and analyzing MLANA-specific T cells. Stability and ease of use are additional bonuses.
Fantastic for Detailed Analysis
In studying melanoma responses, the faithful performance of this tetramer has yielded thorough analyses with clarity. It's engineered for excellence, providing the kind of detailed data that is crucial for breakthrough discoveries.
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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