Anti-MLANA immunotoxin (Fab)-PE
CAT#: AGTO-G050E
This immunotoxin was achieved by conjugating/fusing the Anti-MLANA Fab to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to cancer cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating Human melanoma Xenografts.
Gene Expression
Normal Tissue
Figure 1 High expression in skin 1
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48662/167996_B_8_1_val_selected.jpg
Normal Tissue
Figure 2 Low expression in liver
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48662/167996_A_8_4_val_selected.jpg
Normal Tissue
Figure 3 Testis
Leydig cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48662/167996_A_5_6.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enriched (SK-MEL-30)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120215-MLANA
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Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Molecule Class
- Fab-PE
- Toxin Description
- Pseudomonas aeruginosa exotoxin (Pseudomonas Aeruginosa Exotoxin A, PE) is a cell toxin produced by P. aeruginosa. Divided into three domains in space. DomainIII (s 405~613 amino acids) having ADP ribosylation activity, can inhibit protein synthesis, PE on toxicity mechanisms of cell depends on its Domainlll. After PE molecules into mammals, Domain Ia and widely distributed in mammalian cells α 2 macroglobulin receptor binding was endocytic, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Human Melanoma Xenografts
Target
- Alternative Names
- MLANA; melan-A; MART1; MART-1; melanoma antigen recognized by T-cells 1; antigen LB39-AA; antigen SK29-AA; protein Melan-A; Pseudomonas exotoxin; Pseudomonas exotoxin A; Pseudomonas aeruginosa exotoxin; Pseudomonas aeruginosa exotoxin A; PE; PE38; PE40; ETA; PE33; PE76
- Gene ID
- 2315
- UniProt ID
- Q16655
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1380z | Mouse Anti-MLANA Recombinant Antibody (clone 22A7) | ELISA, FC, ICC, IF, IHC, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
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| NABL-096 | Recombinant Anti-human MLANA VHH Single Domain Antibody | WB, IHC, FC, FuncS | Llama VHH |
| CAT | Product Name | Application | Type |
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| MOB-0324MZ | Recombinant Mouse Anti-Human MLANA Antibody (clone B104) | IHC | Mouse antibody |
| CAT | Product Name | Application | Type |
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| MHC-LC001 | A*02:01/Human Mart-1 (ELAGIGILTV) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1031 | PE-A*02:01/Human MLANA (EAAGIGILTV) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1151 | PE-A2*02:01/Human MLANA (ALGIGILTV) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1364 | PE-HLA-A2/Human MLANA (LAGIGILTV) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1367 | PE-HLA-A2/Human MLANA (AAGIGILTV) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2240 | Hi-Affi™ Recombinant Rabbit Anti-MLANA Monoclonal Antibody (DS2240AB) | IHC-P, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-1008LC | Recombinant Mouse Anti-MLANA Antibody (Mab-1) | WB | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-0579CQ | Recombinant Human Anti-Human MLANA Antibody (E6) | ELISA, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-0580CQ | Recombinant Human Anti-Human MLANA Antibody (H4) | ELISA, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-147CQ | Mouse Anti-Human MLANA Antibody (MOB-147CQ) | WB, IP, IF, IHC-P, FC | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-0987-CN | Recombinant Rabbit Anti-MLANA Monoclonal Antibody (CBACN-366) | WB, IHC, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0096F | Mouse Anti-MLANA Recombinant Antibody (MOB-0096F) | IHC-P, IF | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4411 | Anti-MLANA Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4412 | Anti-Mouse MLANA Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4413 | Anti-Canine MLANA Immunohistochemistry Kit | IHC |
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