PE-I-Ab/OVA (ISQAVHAAHAEINEAGR) MHC Tetramer
CAT#: MHC-LC657
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of OVA-derived peptide of ISQAVHAAHAEINEAGR sequence covering 323-339 and I-Ab molecule. The pMHC tetramer recognizes mouse CD4 T cells, and can be used in the analysis of individual antigen-specific T cells.
Specifications
- Allele
- I-Ab
- Class
- Class II
- MHC Species
- Mouse
- Antigen
- OVA
- Antigen Species
- Gallus gallus
- Peptide
- ISQAVHAAHAEINEAGR
- Range
- 323-339
- Conjugate
- PE
- Application
- FCM
Target
- Antigen Introduction
- Ovalbumin (abbreviated OVA) is the main protein found in egg white, making up approximately 55% of the total protein. Ovalbumin displays sequence and three-dimensional homology to the serpin superfamily, but unlike most serpins it is not a serine protease inhibitor. The function of ovalbumin is unknown, although it is presumed to be a storage protein.
- Alternative Names
- OVA; Ovalbumin
- Gene ID
- 396058
- UniProt ID
- P01012
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Excellent for T Cell Analysis
Having used the PE-I-Ab/OVA MHC Tetramer, I found it an invaluable tool for precise detection and analysis of antigen-specific T cells. The fluorescent PE labeling made flow cytometry seamless and informative, greatly enhancing our understanding of immune cell dynamics in our research on autoimmune pathways.
Enhanced Sensitivity and Detection
The enhanced sensitivity offered by this tetramer over traditional methods was clear in our experiments. It helped capture low-frequency antigen-specific T cells, a crucial factor for our cancer immunology research, better guiding our therapeutic strategies.
Supports Aging Study Research
Ideal for characterizing how aging affects antigen-specific T cell responses-critical in our investigation of differential immune responses in older populations.
Q&As
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What is the main target of this MHC tetramer?
A: The main target of this MHC tetramer is the CD4 T cells in mice. It specifically recognizes T cells that are antigen-specific for the ovalbumin peptide sequence ISQAVHAAHAEINEAGR, which is part of the OVA protein commonly used in research.
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Can the product be used to study autoimmune diseases?
A: Yes, the tetramer can be used to study autoimmune diseases by analyzing the response of CD4 T cells to specific antigens like OVA, providing insights into T cell functionality and autoantigen recognition mechanisms.
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Why is PE conjugation used in this product?
A: PE (phycoerythrin) is a fluorescent dye used to label the MHC tetramer, allowing for flow cytometric analysis to detect and quantify specific T cells in a mixed population.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
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Datasheet
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COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "OVA"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC648 | BV421-H-2Kb/OVA (SIINFEKL) MHC Tetramer | FCM | |
| MHC-LC649 | PE-H-2Kb/OVA (SIINFEKL) MHC Tetramer | FCM | |
| MHC-LC650 | APC-H-2Kb/OVA (SIINFEKL) MHC Tetramer | FCM | |
| MHC-LC651 | PE-H-2Kb/OVA (EIINFEKL) MHC Tetramer | FCM | |
| MHC-LC652 | APC-H-2Kb/OVA (EIINFEKL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-0167CQ | Mouse Anti-OVA Recombinant Antibody (clone Nos. 4) | WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0047 | APC-H-2Kb/Human OVA Mut (EIINFEKL) MHC Tetramer | FCM | |
| MHC-CN0048 | PE-H-2Kb/Human OVA Mut (EIINFEKL) MHC Tetramer | FCM | |
| MHC-CN0265 | APC-H-2Kb/Human OVA (SIINFEKL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1221WJ | Recombinant Dromedary Anti-OVA Single Domain Antibody (HPAB-1221WJ) | ELISA | Dromedary VHH |
| HPAB-1222WJ | Recombinant Dromedary Anti-OVA Single Domain Antibody (HPAB-1222WJ) | ELISA | Dromedary VHH |
| HPAB-1223WJ | Recombinant Dromedary Anti-OVA Single Domain Antibody (HPAB-1223WJ) | ELISA | Dromedary VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-0332C | Mouse Anti-OVA Recombinant Antibody (ZG-0332C) | WB, ELISA | Mouse IgG |
| ZG-487C | Mouse Anti-OVA Recombinant Antibody (clone 5A7A7) | ELISA | Mouse IgG1, κ |
| VS7-0425-WR529 | Mouse Anti-OVA Monoclonal Antibody (clone 3G2E1D9) | WB | Mouse IgG1 |
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