Recombinant Anti-Human CXCL8 Antibody (Fc glycosylation) (CAT#: Gly-095LC)
This product is a humanized monoclonal antibody with N-glycosylation site in the Fc region. The antibody aIL8-hFc with enhanced ADCC specifically binds human IL-8 and can be potentially used in the treatment of inflammatory disease.
Specific Inquiry
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57179/1010_F11_1_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57179/1010_F11_1_selected.jpg
Figure 2 IHC staining of human lymph node
(Immunohistochemical staining of human lymph node shows moderate cytoplasmic positivity in non germinal center cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57179/ihc_selected.jpg
(Immunohistochemical staining of human lymph node shows moderate cytoplasmic positivity in non germinal center cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57179/ihc_selected.jpg
Figure 3 IF staining of human cell line GAMG
(Immunofluorescent staining of human cell line GAMG shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57179/2058_E8_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line GAMG shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57179/2058_E8_1_blue_red_green.jpg
Figure 4 Kidney
(Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57179/131156_A_7_5.jpg
(Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57179/131156_A_7_5.jpg
Figure 5 Testis
(Sertoli cells
Staining:Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57179/131156_A_6_6.jpg
(Sertoli cells
Staining:Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57179/131156_A_6_6.jpg
Figure 6 Lymph node
(Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57179/131156_A_8_8.jpg
(Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57179/131156_A_8_8.jpg
Figure 7 RNA cell line category: Group enriched (BJ hTERT+, GAMG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000169429-CXCL8
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000169429-CXCL8
Glyco-engineering
- Glycosylation site
- Fc region
- Glycoform (ratio)
- G0 (55%)
G1 (34%)
- Glycosylation Type
- N-glycosylation
- Activity
- Enhanced ADCC
Specifications
- Target
- IL-8 (Interleukin 8)
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized antibody
- Specificity
- Human
- Antibody Isotype
- IgG1
- Clone
- aIL8-hFc
- Expression Host
- CHO-DP12
- Applications
- ELISA
Target
- Alternative Names
- CXCL8; chemokine (C-X-C motif) ligand 8; IL8; NAF; GCP1; LECT; LUCT; NAP1; GCP-1; LYNAP; MDNCF; MONAP; NAP-1; interleukin-8; emoctakin; interleukin 8; T-cell chemotactic factor; neutrophil-activating peptide 1; beta-thromboglobulin-like protein; granulocy
- Related Disease
- Inflammatory diseas
- Gene ID
- 3576
- UniProt ID
- A0A024RDA5
Downloads
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-738-sdAb | Recombinant Anti-human CXCL8 VHH Single Domain Antibody | IHC, ICC, FC, FA, FUNC | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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