Recombinant Anti-Human FCER2 Antibody (Fc glycosylation/Non fucosylated)

Name: Recombinant Anti-Human FCER2 Antibody (Fc glycosylation/Non fucosylated)
SKU: Gly-157LC
Rating: 5 (1 reviews)

CAT#: Gly-157LC

This product is a non-fucosylated chimeric (primate/human) monoclonal antibody. The antibody with enhanced ADCC specficfically binds to human CD23 and can be potentially used in the treatment of chronic lymphocytic leukemia.

Gene Expression

Normal Tissue Figure 1 High expression in lymph node

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8928/24032_A_9_8_val_selected.jpg

Normal Tissue Figure 2 Low expression in endometrium 1

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8928/24032_B_4_3_val_selected.jpg

Normal Tissue Figure 3 Bone marrow

Hematopoietic cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2624/6435_B_5_4.jpg

Normal Tissue Figure 4 Lymph node

Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2624/6435_A_9_8.jpg

RNA Expression Figure 5 RNA cell line category: Cell line enriched (HDLM-2)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000104921-FCER2

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Glyco-engineering

Glycosylation site
Fc region

Glycosylation Type
N-glycosylation

Activity
Enhanced ADCC

Specifications

Target
CD23 (Cluster of differentiation-23)

Host Species
Human

Derivation
Chimeric (primate/human)

Type
Chimeric antibody (primate/human)

Specificity
Human

Applications
ELISA

Target

Alternative Names
FCER2; Fc fragment of IgE receptor II; CD23; FCE2; CD23A; IGEBF; CLEC4J; BLAST-2

Related Disease
Chronic lymphocytic leukemia

Gene ID
2208

UniProt ID
P06734

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Downloadable Resources

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Datasheet

Datasheet - Gly-157LC.pdf

MSDS

MSDS - Gly-157LC.pdf

COA

Certificate of Analysis Lookup

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