Human Anti-FCER2 (clone 1E9) scFv-Fc Chimera
CAT#: VS-0425-FY83
This fusion protein targets FCER2 (Fc epsilon RII/CD23), a low-affinity receptor for IgE involved in allergic responses. It is being explored for its potential use in treating allergic diseases by modulating IgE signaling.
Gene Expression
Normal Tissue
Figure 1 High expression in lymph node
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8928/24032_A_9_8_val_selected.jpg
Normal Tissue
Figure 2 Low expression in endometrium 1
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8928/24032_B_4_3_val_selected.jpg
Normal Tissue
Figure 3 Bone marrow
Hematopoietic cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2624/6435_B_5_4.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2624/6435_A_9_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enriched (HDLM-2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000104921-FCER2
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Specifications
- Immunogen
- Recombinant human CD23 protein produced in E. coli.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human FCER2
- Species Reactivity
- Human
- Clone
- Clone 1E9
- Applications
- ELISA
- Related Disease
- Chronic Conjunctivitis and Extrinsic Allergic Alveolitis
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Fc Fragment Of IgE Receptor II; Fc Fragment Of IgE, Low Affinity II, Receptor For (CD23); Immunoglobulin E-Binding Factor; Lymphocyte IgE Receptor; Fc Epsilon Receptor II; Fc-Epsilon-RII; CD23 Antigen; BLAST-2; CLEC4J; CD23A
- Gene ID
- 2208
- UniProt ID
- P06734
- Long Name
- Fc Fragment Of IgE Receptor II
- Cellular Localization
- Cell membrane, Membrane, Secreted
- Post Translation Modifications
- N- and O-glycosylated.
The secreted form sCD23 is produced by ADAM10-mediated ectodomain shedding.
- Protein Refseq
- NP_001193948.2; NP_001207429.1; NP_001993.2
- Function
- Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-157LC | Recombinant Anti-Human FCER2 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Chimeric antibody (primate/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-157LC-1 | Recombinant Anti-Human FCER2 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Chimeric antibody (primate/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0281MZ | Recombinant Mouse Anti-Human Fc fragment of IgE, low affinity II, receptor for (CD23) Antibody (clone NHM7) | IHC | Mouse antibody |
| MOB-030LC | Human Anti-FCER2 Recombinant Antibody (clone p6G5) | ELISA, FuncS | Chimeric (primate/human) IgG1 |
| HPAB-A1301-YJ | Mouse Anti-FCER2 Recombinant Antibody (clone C11) | ELISA | Mouse IgG2a |
| HPAB-A1302-YJ | Human Anti-FCER2 Recombinant Antibody (clone chC11) | ELISA | Chimeric (mouse/human) IgG1 |
| VS3-CJ449 | Mouse Anti-FCER2 Recombinant Antibody (VS3-CJ449) | WB, IHC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-786CQ | Mouse Anti-FCER2 Recombinant Antibody (clone CBL016) | Neut, FC, WB | Mouse IgG2 |
| NEUT-788CQ | Mouse Anti-FCER2 Recombinant Antibody (clone MM0164-2C23) | WB, Neut, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-787CQ | Mouse Anti-FCER2 Recombinant Antibody (clone TU1) | FC, IHC-Fr, ICC, WB, Block | Mouse IgG3, κ |
| NEUT-789CQ | Mouse Anti-FCER2 Recombinant Antibody (clone CBL329) | ELISA, WB, Block, CyTOF®, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1268 | Hi-Affi™ Rabbit Anti-FCER2 Recombinant Antibody (clone DS1268AB) | IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-231 | Afuco™ Anti-FCER2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-231) | Neut, ELISA, IF, IP, FuncS | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1148-FY-F(E) | Human Anti-FCER2 Recombinant Antibody; Fab Fragment (HPAB-1148-FY-F(E)) | Activ | Human Fab |
| HPAB-1149-FY-F(E) | Monkey Anti-FCER2 Recombinant Antibody; Fab Fragment (HPAB-1149-FY-F(E)) | Activ | Monkey Fab |
| HPAB-0530-YJ-S(P) | Mouse Anti-FCER2 Recombinant Antibody (clone 1E9); scFv Fragment | ELISA, IHC | Mouse scFv |
| HPAB-0531-YJ-S(P) | Human Anti-FCER2 Recombinant Antibody (clone ch1E9); scFv Fragment | ELISA, IHC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1148-FY-S(P) | Monkey Anti-FCER2 Recombinant Antibody; scFv Fragment (HPAB-1148-FY-S(P)) | Activ | Monkey scFv |
| HPAB-1149-FY-S(P) | Monkey Anti-FCER2 Recombinant Antibody; scFv Fragment (HPAB-1149-FY-S(P)) | Activ | Monkey scFv |
| HPAB-0530-YJ-F(E) | Mouse Anti-FCER2 Recombinant Antibody (clone 1E9); Fab Fragment | ELISA, IHC | Mouse Fab |
| HPAB-0531-YJ-F(E) | Human Anti-FCER2 Recombinant Antibody (clone ch1E9); Fab Fragment | ELISA, IHC | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY111 | CytoStream™ Mouse Anti-FCER2 Recombinant Antibody (clone EBVCS-5) | FC | Mouse IgG1, kappa |
| VS13-YC385 | CytoStream™ Rabbit Anti-FCER2 Recombinant Antibody (VS13-YC385) | IHC-P, ICC, IF, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC203 | Recombinant Anti-FCER2 Vesicular Antibody, EV Displayed (VS-0425-YC203) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2478 | Anti-FCER2 Immunohistochemistry Kit | IHC |
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