Recombinant Human Anti-human BRCA1 Antibody (CAT#: MHH-123)
Recombinant Human Antibody raises against Human BRCA1, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-BRCA1 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-BRCA1 mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line RH-30
(Immunofluorescent staining of human cell line RH-30 shows localization to nucleoplasm & nuclear bodies.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4840/1914_E5_15_cr5c8770e98e94d_selected.jpg
(Immunofluorescent staining of human cell line RH-30 shows localization to nucleoplasm & nuclear bodies.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4840/1914_E5_15_cr5c8770e98e94d_selected.jpg
Figure 2 IHC staining of human testis
(Immunohistochemical staining of human testis shows strong nuclear positivity in a subset of cells in seminiferous ducts.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/34966/89241_A_4_6_selected.jpg
(Immunohistochemical staining of human testis shows strong nuclear positivity in a subset of cells in seminiferous ducts.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/34966/89241_A_4_6_selected.jpg
Figure 3 Cerebral cortex
(Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1946/5290_B_8_5.jpg
(Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1946/5290_B_8_5.jpg
Figure 4 Colon
(Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1946/5290_A_9_3.jpg
(Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1946/5290_A_9_3.jpg
Figure 5 Testis
(Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1946/5290_A_6_6.jpg
(Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1946/5290_A_6_6.jpg
Figure 6 Skin
(Epidermal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1946/5290_B_5_8.jpg
(Epidermal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1946/5290_B_5_8.jpg
Figure 7 Lymph node
(Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Nuclear
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1946/5290_A_8_8.jpg
(Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Nuclear
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1946/5290_A_8_8.jpg
Figure 8 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000012048-BRCA1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000012048-BRCA1
Specifications
- Immunogen
- Human breast cancer 1, early onset
- Host Species
- Human
- Derivation
- Human
- Type
- IgG
- Specificity
- Tested positive against native Human breast cancer 1, early onset
- Species Reactivity
- Human
- Applications
- Can be useful in applications such as: Flow Cytometry; Enzyme-linked Immunosorbent Assay; Functional Study
Product Property
- Purity
- >97%, by SDS-PAGE under reducing conditions
- Storage
- Store at -20°C for long-term storage. Store at 4°C for up to one month. Avoid freeze/thaw cycles.
Target
- Alternative Names
- BRCA1; breast cancer 1, early onset; IRIS; PSCP; BRCAI; BRCC1; FANCS; PNCA4; RNF53; BROVCA1; PPP1R53; breast cancer type 1 susceptibility protein; RING finger protein 53; Fanconi anemia, complementation group S; BRCA1/BRCA2-containing complex, subunit 1;
- Gene ID
- 672
- UniProt ID
- P38398
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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IgG Antibodies
Fab Antibodies
ScFv Antibodies
Chicken IgY Antibodies
IHC Kits & Antibodies
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-123 | Recombinant Anti-human BRCA1 Antibody | ELISA, WB, Neut, FuncS | IgG |
| MOB-1473MZ | Mouse Anti-BRCA1 Recombinant Antibody (clone 7C5) | IP, WB | Mouse IgG1 |
| VS3-XY137 | Mouse Anti-BRCA1 Recombinant Antibody (clone 6C6D2) | ELISA, WB, IHC | Mouse IgG1 |
| VS3-WK1325 | Mouse Anti-BRCA1 Recombinant Antibody (VS3-WK1325) | ELISA, WB | Mouse IgG |
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